Imaging and drug delivery using theranostic nanoparticles.
Imaging and drug delivery using theranostic nanoparticles.
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DOI：
10.1016/j.addr.2010.08.004
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发表时间：
2010-08-30
影响因子：
16.1
通讯作者：
MacKay, J. Andrew
中科院分区：
文献类型：
--
作者：
Janib, Siti M.;Moses, Ara S.;MacKay, J. Andrew
关键词：
纳米颗粒技术正在对治疗和诊断试剂的发展产生重大影响。在治疗和诊断的交叉点上，人们对将这两种范例结合成临床有效的配方越来越感兴趣。这一概念最近被称为治疗学，与以疾病分子生物标记物为靶标的药物高度相关，有望为个性化医学做出贡献。在这里，我们从治疗和诊断的角度回顾最新的纳米粒子，并讨论将这些领域结合在一起的挑战。纳米粒子的主要类别包括药物结合物和络合物、树枝状大分子、囊泡、胶束、核壳粒子、微泡和碳纳米管。这些制剂中的大多数都被描述为药物或造影剂的载体。为了观察这些制剂及其与疾病的相互作用，使用了各种造影剂，包括光学活性小分子、金属和金属氧化物、超声波造影剂和放射性核素。快速评估和调整治疗以适应个人需要的机会提供了潜在的优势，将刺激治疗药物的发展。
Nanoparticle technologies are significantly impacting the development of both therapeutic and diagnostic agents. At the intersection between treatment and diagnosis, interest has grown in combining both paradigms into clinically effective formulations. This concept, recently coined as theranostics, is highly relevant to agents that target molecular biomarkers of disease and is expected to contribute to personalized medicine. Here we review state-of-the-art nanoparticles from a therapeutic and a diagnostic perspective and discuss challenges in bringing these fields together. Major classes of nanoparticles include, drug conjugates and complexes, dendrimers, vesicles, micelles, core–shell particles, microbubbles, and carbon nanotubes. Most of these formulations have been described as carriers of either drugs or contrast agents. To observe these formulations and their interactions with disease, a variety of contrast agents have been used, including optically active small molecules, metals and metal oxides, ultrasonic contrast agents, and radionuclides. The opportunity to rapidly assess and adjust treatment to the needs of the individual offers potential advantages that will spur the development of theranostic agents.
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影响因子：
17.1
作者：
Bhirde, Ashwin A.;Patel, Vyomesh;Gavard, Julie;Zhang, Guofeng;Sousa, Alioscka A.;Masedunskas, Andrius;Leapman, Richard D.;Weigert, Roberto;Gutkind, J. Silvio;Rusling, James F.
通讯作者：
Rusling, James F.
影响因子：
10.9
作者：
Baiker, Martin;Milles, Julien;Lelieveldt, Boudewijn P. F.
通讯作者：
Lelieveldt, Boudewijn P. F.
影响因子：
10.8
作者：
Borgman, Mark P.;Coleman, Tomika;Kolhatkar, Rohit B.;Geyser-Stoops, Sandra;Line, Bruce R.;Ghandehari, Hamidreza
通讯作者：
Ghandehari, Hamidreza
影响因子：
3.8
作者：
AlkanOnyuksel, H;Demos, SM;McPherson, DD
通讯作者：
McPherson, DD
影响因子：
5.8
作者：
Bidwell, Gene L., III;Fokt, Izabela;Raucher, Drazen
通讯作者：
Raucher, Drazen