Comparative genomics of flatworms (platyhelminthes) reveals shared genomic features of ecto- and endoparastic neodermata.
Comparative genomics of flatworms (platyhelminthes) reveals shared genomic features of ecto- and endoparastic neodermata.
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DOI：
10.1093/gbe/evu078
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发表时间：
2014-05
影响因子：
3.3
通讯作者：
Bachmann L
中科院分区：
文献类型：
--
作者：
Hahn C;Fromm B;Bachmann L
外寄生单殖吸虫是专性寄生扁形虫多样性的主要组成部分。虽然基因组适应寄生已研究内寄生绦虫（绦虫）和吸虫（吸虫），还没有代表单殖吸虫进行了调查。我们提出了高质量的基因组草图三代鱼，一个经济上重要的单殖吸虫体外寄生的野生大西洋鲑鱼（萨尔莫salar）。共鉴定了15，488个基因模型，其中7，102个进行了功能注释。专性寄生性新皮门内有争议的系统发育关系在一个基因组分析中得到解决，该分析使用了1，719个基因模型（比对长度> 500，000个氨基酸），用于一组16个后生动物分类群。单殖吸虫被发现在绦虫纲和吸虫纲的基础上，这意味着外寄生在Neodermata中是近形的，并强烈支持复杂生活史的共同起源。7寄生扁形虫基因组的比较分析确定了共同的基因组特征的外寄生和内寄生谱系，如大量减少的核心两侧基因的补充，包括同源结构域的基因，和损失的piwi和vasa基因，这被认为是必不可少的动物发育。此外，功能性脂肪酸生物合成途径的共享损失和过氧化物酶体的情况下，后者的细胞器推测普遍存在于真核生物中，除了寄生原生动物，推断。对G. salaris为进一步深入研究G. salaris菌株，并将加强对宿主-寄生虫相互作用和高度多样化的单殖吸虫扁虫物种形成的基因组学研究。
The ectoparasitic Monogenea comprise a major part of the obligate parasitic flatworm diversity. Although genomic adaptations to parasitism have been studied in the endoparasitic tapeworms (Cestoda) and flukes (Trematoda), no representative of the Monogenea has been investigated yet. We present the high-quality draft genome of Gyrodactylus salaris, an economically important monogenean ectoparasite of wild Atlantic salmon (Salmo salar). A total of 15,488 gene models were identified, of which 7,102 were functionally annotated. The controversial phylogenetic relationships within the obligate parasitic Neodermata were resolved in a phylogenomic analysis using 1,719 gene models (alignment length of >500,000 amino acids) for a set of 16 metazoan taxa. The Monogenea were found basal to the Cestoda and Trematoda, which implies ectoparasitism being plesiomorphic within the Neodermata and strongly supports a common origin of complex life cycles. Comparative analysis of seven parasitic flatworm genomes identified shared genomic features for the ecto- and endoparasitic lineages, such as a substantial reduction of the core bilaterian gene complement, including the homeodomain-containing genes, and a loss of the piwi and vasa genes, which are considered essential for animal development. Furthermore, the shared loss of functional fatty acid biosynthesis pathways and the absence of peroxisomes, the latter organelles presumed ubiquitous in eukaryotes except for parasitic protozoans, were inferred. The draft genome of G. salaris opens for future in-depth analyses of pathogenicity and host specificity of poorly characterized G. salaris strains, and will enhance studies addressing the genomics of host–parasite interactions and speciation in the highly diverse monogenean flatworms.
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影响因子：
14.9
作者：
Kanehisa M;Goto S;Sato Y;Furumichi M;Tanabe M
通讯作者：
Tanabe M
影响因子：
2.4
作者：
Cable, J;Tinsley, RC;Harris, PD
通讯作者：
Harris, PD
影响因子：
4.3
作者：
Gentile L;Cebrià F;Bartscherer K
通讯作者：
Bartscherer K
影响因子：
4
作者：
Hansen, H;Bachmann, L;Bakke, TA
通讯作者：
Bakke, TA
使用orthomcl将蛋白质分配给Orthomcl-DB组或将蛋白质组群集分为新的直系同源组。
影响因子：
--
作者：
Fischer, Steve;Brunk, Brian P;Chen, Feng;Gao, Xin;Harb, Omar S;Iodice, John B;Shanmugam, Dhanasekaran;Roos, David S;Stoeckert, Christian J Jr
通讯作者：
Stoeckert, Christian J Jr