Vitamin B-12 Status Differs among Pregnant, Lactating, and Control Women with Equivalent Nutrient Intakes
Vitamin B-12 Status Differs among Pregnant, Lactating, and Control Women with Equivalent Nutrient Intakes
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DOI：
10.3945/jn.115.210757
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发表时间：
2015-07-01
影响因子：
4.2
通讯作者：
Caudill, Marie A.
中科院分区：
文献类型：
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作者：
Bae, Sajin;West, Allyson A.;Caudill, Marie A.
目的：我们试图量化怀孕和哺乳对维生素B-12摄入量的影响。方法：作为10-12wk喂养试验的一部分，怀孕(26-29wk妊娠；n=26)、哺乳期(产后5wk；n=28)和对照组(未怀孕，非哺乳期；N=21)妇女摄入的维生素B-12的量类似于8.6微克/天(混合饮食(类似于6微克/天)加上产前复合维生素补充剂(2.6微克/天)]。在基线和研究结束时检测血清维生素B-12、全反钴胺(维生素B-12的生物活性形式)、甲基丙二酸(MMA)和同型半胱氨酸。结果：所有参与者在研究剂量后都达到了足够的维生素B-12水平。与对照组相比，研究结束时孕妇血清维生素B-12水平较低(-21%；P=0.02)，而哺乳期妇女血清维生素B-12水平较高(P=0.04)(研究结束时为+26%)。摄入研究剂量的维生素B-12会增加所有生育组的血清全反钴胺(+16-42%；P
Background: Limited data are available from controlled studies on biomarkers of maternal vitamin B-12 status.Objective: We sought to quantify the effects of pregnancy and lactation on the vitamin B-12 status response to a known and highly controlled vitamin B-12 intake.Methods: As part of a 10-12 wk feeding trial, pregnant (26-29 wk gestation; n = 26), lactating (5 wk postpartum; n = 28), and control (nonpregnant, nonlactating; n = 21) women consumed vitamin B-12 amounts of similar to 8.6 mu g/d (mixed diet (similar to 6 mu g/d) plus a prenatal multivitamin supplement (2.6 mu g/d)]. Serum vitamin B-12, holotranscobalamin (bioactive form of vitamin B-12), methylmalonic acid (MMA), and homocysteine were measured at baseline and study-end.Results: All participants achieved adequate vitamin B-12 status in response to the study dose. Compared with control women, pregnant women had lower serum vitamin B-12 (-21%; P = 0.02) at study-end, whereas lactating women had higher (P=0.04) serum vitamin B-12 throughout the study (+26% at study-end). Consumption of the study vitamin B-12 dose increased serum holotranscobalamin in all reproductive groups (+16-42%; P