The desmopressin test in the differential diagnosis between Cushing's disease and pseudo-Cushing states
The desmopressin test in the differential diagnosis between Cushing's disease and pseudo-Cushing states
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DOI：
10.1210/jc.85.10.3569
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发表时间：
2000-10-01
影响因子：
5.8
通讯作者：
Cavagnini, F
中科院分区：
文献类型：
--
作者：
Moro, M;Putignano, P;Cavagnini, F
鉴别库欣病（CD）和伪库欣病（PC）在目前的实践中仍然是困难的。由于去氨加压素（1-去氨基- 8d -精氨酸抗利尿素，DDAVP）是一种抗利尿素类似物，在CD患者中刺激ACTH释放，但在大多数正常、肥胖和抑郁受试者中却没有，因此我们研究了它区分CD和PC状态的能力；173名受试者（76名患有活动性CD， 30名患有PC， 36名患有单纯性肥胖，31名健康志愿者）接受了静脉注射10 μ g DDAVP的测试。其中61名受试者还进行了生理盐水对照研究。DDAVP诱导CD患者ACTH和皮质醇显著升高(P
Differentiating Cushing's disease (CD) from pseudo-Cushing (PC) states may still be difficult in current practice. Because desmopressin (1-deamino-8D-arginine vasopressin, DDAVP), a vasopressin analogue, stimulates ACTH release in patients with CD but not in the majority of normal, obese, and depressed subjects, we investigated its ability to discriminate CD from PC states; One hundred seventy-three subjects (76 with active CD, 30 with PC, 36 with simple obesity, and 31 healthy volunteers) were tested with an iv bolus of 10 mu g DDAVP. Sixty-one of these subjects also underwent a control study with saline. DDAVP induced marked ACTH and cortisol rises in CD (P