Coxiella burnetii Shedding by Farmed Red Deer (Cervus elaphus)
Coxiella burnetii Shedding by Farmed Red Deer (Cervus elaphus)
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DOI：
10.1111/tbed.12179
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发表时间：
2015-10-01
影响因子：
4.3
通讯作者：
Ruiz-Fons, F.
中科院分区：
文献类型：
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作者：
Gonzalez-Barrio, D.;Almeria, S.;Ruiz-Fons, F.
野生动物，特别是鹿的物种-由于全世界养鹿的相关性越来越大-可能有助于维持贝氏柯克斯体，Q热的病原体。目前，还没有将接触鹿类与人类Q热病例联系起来的先例。然而，最近在一个红鹿（马鹿）养殖场诊断出一例Q热人间病例，这使我们调查鹿是否可能是贝氏隐孢子虫环境污染的来源，并确定贝氏隐孢子虫在养殖场繁殖失败中的意义。从经历或未经历生殖失败的母鹿中采集血清和阴道拭子，并分别检测贝氏衣原体、流产衣原体、犬新孢子虫和刚地弓形虫的抗体和DNA的存在。血清学和PCR结果表明贝氏隐孢子虫是导致繁殖失败的主要原因。我们在母鹿中鉴定出贝氏隐孢子虫的阴道散毒，证实红鹿是Q热人畜共患感染的来源。
Wildlife and notably deer species - due to the increasing relevance of deer farming worldwide - may contribute to the maintenance of Coxiella burnetii, the causal agent of Q fever. Currently, there are no precedents linking exposure to deer species with human Q fever cases. However, a human case of Q fever was recently diagnosed in a red deer (Cervus elaphus) farm, which led us to investigate whether deer could be a source for environmental contamination with C.burnetii and ascertain the implication of C.burnetii in reproductive failure in the farm. Blood serum and vaginal swabs were collected from hinds either experiencing or not reproductive failure and tested to detect the presence of antibodies and DNA, respectively, of C.burnetii, Chlamydia abortus, Neospora caninum and Toxoplasma gondii. Serology and PCR results suggest C.burnetii was the primary cause of the reproductive failure. We identified vaginal shedding of C.burnetii in hinds, confirming red deer as a source of Q fever zoonotic infection.