Characteristics and Outcome After Hospitalization for Acute Right Heart Failure in Patients With Pulmonary Arterial Hypertension
Characteristics and Outcome After Hospitalization for Acute Right Heart Failure in Patients With Pulmonary Arterial Hypertension
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DOI：
10.1161/circheartfailure.110.949933
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发表时间：
2011-11-01
影响因子：
9.7
通讯作者：
Zamanian, Roham T.
中科院分区：
文献类型：
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作者：
Haddad, Francois;Peterson, Tyler;Zamanian, Roham T.
背景-虽然我们对急性心力衰竭和左心室功能不全住院患者预后不良的危险因素了解很多，但对主要影响右心室的急性心力衰竭综合征（急性右心衰竭）了解甚少。方法和结果-通过使用斯坦福大学医院的肺动脉高压数据库，我们确定了PAH患者连续急性右心衰竭住院。我们采用广义估计方程法进行纵向回归分析，以确定与90天死亡率或紧急移植可能性增加相关的因素。1999年6月至2009年9月，119例PAH患者因急性右心衰竭住院（207次发作）。34例患者在入院90天内死亡或紧急移植。多变量分析确定入院时呼吸频率较高（>20次/min; OR，3.4; 95%CI，1.5-7.8），入院时肾功能不全（肾小球滤过率
Background-Although much is known about the risk factors for poor outcome in patients hospitalized with acute heart failure and left ventricular dysfunction, much less is known about the syndrome of acute heart failure primarily affecting the right ventricle (acute right heart failure).Methods and Results-By using Stanford Hospital's pulmonary hypertension database, we identified consecutive acute right heart failure hospitalizations in patients with PAH. We used longitudinal regression analysis with the generalized estimating equations method to identify factors associated with an increased likelihood of 90-day mortality or urgent transplantation. From June 1999 to September 2009, 119 patients with PAH were hospitalized for acute right heart failure (207 episodes). Death or urgent transplantation occurred in 34 patients by 90 days of admission. Multivariable analysis identified a higher respiratory rate on admission (>20 breaths per minute; OR, 3.4; 95% CI, 1.5-7.8), renal dysfunction on admission (glomerular filtration rate