Adiponectin as a biomarker of the metabolic syndrome
Adiponectin as a biomarker of the metabolic syndrome
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DOI：
10.1253/circj.68.975
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发表时间：
2004-11-01
影响因子：
3.3
通讯作者：
Funahashi, T
中科院分区：
文献类型：
--
作者：
Ryo, M;Nakamura, T;Funahashi, T
背景代谢综合征是一组腹部肥胖、血脂异常、高血压和高血糖症，是暴露于营养过剩的工业化国家动脉粥样硬化血管疾病的常见基础。脂联素是一种脂肪来源的血浆蛋白，具有抗动脉粥样硬化和胰岛素增敏活性。方法和结果共661名日本成年人（479名男性，53 +/- 10岁; 182名女性56 +/- 10岁）参加。血浆脂联素浓度与男性和女性的腰围、内脏脂肪面积、血清甘油三酯浓度、空腹血糖、空腹血浆胰岛素、收缩压和舒张压呈负相关。血浆脂联素和高密度脂蛋白胆固醇浓度之间呈正相关。随着血浆脂联素浓度的降低，代谢综合征的平均组分数增加：男性为2.57+/-1.34，女性为2.00+/-1.51
Background The metabolic syndrome, a cluster of abdominal obesity, dyslipidemia, hypertension and hyperglycemia, is a common basis for atherosclerotic vascular diseases in industrial countries exposed to overnutrition. Adiponectin is an adipose-derived plasma protein with anti-atherogenic and insulin-sensitizing activities.Methods and Results A total of 661 Japanese adults (479 men, 53 +/- 10 years; 182 women 56 +/- 10 years) were enrolled. Plasma adiponectin concentrations correlated negatively with waist circumference, visceral fat area, serum triglyceride concentration, fasting plasma glucose, fasting plasma insulin, and systolic and diastolic blood pressure in both sexes. A positive correlation was found between plasma adiponectin and high-density lipoprotein cholesterol concentrations in both sexes. The mean number of components of the metabolic syndrome increased as the plasma adiponectin concentration decreased: 2.57+/-1.34 for men and 2.00+/-1.51 for women with adiponectin concentrations