Structural Properties of Micelles Formed by Telechelic Pentablock Quaterpolymers with pH-Responsive Midblocks and Thermoresponsive End Blocks in Aqueous Solution
Structural Properties of Micelles Formed by Telechelic Pentablock Quaterpolymers with pH-Responsive Midblocks and Thermoresponsive End Blocks in Aqueous Solution
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DOI：
10.1021/acs.macromol.9b01775
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发表时间：
2019-12
期刊：
影响因子：
5.5
通讯作者：
Florian A. Jung;Panayiota A. Panteli;Chia-Hsin Ko;Jia Kang;L. Barnsley;C. Tsitsilianis;C. S. Patrickios;C. Papadakis
中科院分区：
文献类型：
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作者：
Florian A. Jung;Panayiota A. Panteli;Chia-Hsin Ko;Jia Kang;L. Barnsley;C. Tsitsilianis;C. S. Patrickios;C. Papadakis
我们研究了多响应五嵌段四聚体P的自组装动态胶束的结构特性（nBuMA8-co-TEGMA8）-b-PDMAEMA 50-b-PEG46-b-PDMAEMA 50-b-P（nBuMA 8-共-TEGMA 8）（nBuMA、TEGMA、DMAEMA和EG是甲基丙烯酸正丁酯、三（乙二醇）甲基醚甲基丙烯酸酯、2-甲基-2-（三甲基-1，3-二氧杂环戊烯-1-基）-2-（三甲基-1，3-二氧杂环戊烯-1-基）甲基丙烯酸酯、2-甲基-2-（三甲基-1，3-二氧杂环戊烯-1-基）甲基丙烯酸酯。（二甲基氨基）乙基甲基丙烯酸酯和乙二醇）。在该多嵌段聚合物中，来自弱阳离子双链PDMAEMA和亲水性PEG的pH响应性BAB三嵌段共聚物被包含热响应性TEGMA单元和疏水性nBuMA单元的随机序列的两个嵌段封端。动态光散射结果表明，在稀溶液中存在单胶束和小团簇。胶束的流体动力学半径强烈依赖于pH和温度。用小角X射线散射、小角中子散射、X射线衍射等方法研究了胶束的内部结构。
We investigated the structural properties of dynamic micelles arising from the self-assembly of the multiresponsive pentablock quaterpolymer P(nBuMA8-co-TEGMA8)-b-PDMAEMA50-b-PEG46-b-PDMAEMA50-b-P(nBuMA8-co-TEGMA8) (nBuMA, TEGMA, DMAEMA, and EG are n-butyl methacrylate, tri(ethylene glycol) methyl ether methacrylate, 2-(dimethylamino)ethyl methacrylate, and ethylene glycol, respectively) in aqueous solution using a combination of scattering methods. In this multisegmented polymer, a pH-responsive BAB triblock copolymer from the weak cationic polyelectrolyte PDMAEMA and the hydrophilic PEG is end-capped by two blocks comprising random sequences of thermoresponsive TEGMA units and hydrophobic nBuMA units. Dynamic light scattering revealed the existence of single micelles and small clusters in dilute aqueous solution. The hydrodynamic radius of the micelles depends strongly on pH and temperature. The inner structure of the micelles was investigated by small-angle X-ray scattering, small-angle neutron scatter...