Dosimetric implications of age related glandular changes in screening mammography
Dosimetric implications of age related glandular changes in screening mammography
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DOI：
10.1088/0031-9155/45/3/316
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发表时间：
2000-03-01
影响因子：
3.5
通讯作者：
Kotre, CJ
中科院分区：
文献类型：
--
作者：
Beckett, JR;Kotre, CJ
联合王国国家卫生服务乳房检查方案目前正在组织对50至64岁的妇女进行例行检查，老年妇女也可应要求进行检查。这一年龄范围的下限与绝经的中位年龄（51岁）非常接近，在此期间，乳房的组成发生了显着变化。为了量化这些变化的剂量效应，已使用接受乳腺筛查乳房X线摄影的1258名年龄在35岁至79岁之间的女性的放射学因素和压缩乳房厚度数据来估计乳房腺体和平均腺体剂量（MGD），并检查其随年龄的变化。平均射线照射因素随年龄的变化也进行了研究。队列中存在大量年龄试验女性，因此可以研究更大的年龄范围。将MGD的估计值（包括仅基于压缩乳房厚度、压缩乳房厚度和年龄的乳房腺体校正）与基于50：50脂肪/腺体组成的传统假设的MGD进行比较。已经发现，使用传统的50：50假设导致在所考虑的年龄范围内MGD的高估高达13%。通过使用压缩乳房厚度来估计乳房腺体度，该误差范围可以减小到8%，而基于年龄和压缩乳房厚度的腺体度估计导致1%的误差范围。
The UK National Health Service Breast Screening Programme is currently organized to routinely screen women between the ages of 50 and 64, with screening for older women available on request. The lower end of this age range closely matches the median age for the menopause (51 years), during which significant changes in the composition of the breast are known to occur. In order to quantify the dosimetric effect of these changes, radiographic factors and compressed breast thickness data for a cohort of 1258 women aged between 35 and 79 undergoing breast screening mammography have been used to derive estimates of breast glandularity and mean glandular dose (MGD), and examine their variation with age. The variation of mean radiographic exposure factors with age is also investigated. The presence of a significant number of age trial women within the cohort allowed an extended age range to be studied. Estimates of MGD including corrections for breast glandularity based on compressed breast thickness only, compressed breast thickness and age and for each individual woman are compared with the MGD based on the conventional assumption of a 50:50 adipose/glandular composition. It has been found that the use of the conventional 50:50 assumption leads to overestimates of MGD of up to 13% over the age range considered. By using compressed breast thickness to estimate breast glandularity, this error range can be reduced to 8%, whilst age and compressed breast thickness based glandularity estimates result in an error range of 1%.