Basic science of osteoarthritis.
Basic science of osteoarthritis.
复制标题
DOI：
10.1186/s40634-016-0060-6
复制
发表时间：
2016-12
影响因子：
1.8
通讯作者：
Reboul P
中科院分区：
文献类型：
--
作者：
Cucchiarini M;de Girolamo L;Filardo G;Oliveira JM;Orth P;Pape D;Reboul P
骨关节炎(OA)是一种流行的、致残的关节疾病，影响着世界各地的大量人口，目前还没有确定的治疗方法。这篇综述提供了对有关骨性关节炎的基本知识的重要见解，这些知识可能会导致创新的最终有效的新治疗方案。虽然关节软骨的退化是骨关节炎的标志，软骨细胞和细胞外基质化合物之间的相互作用发生了改变，但软骨下骨也被描述为该病的关键组成部分，涉及控制其发生和发展的特定病理机制。许多旨在复制人类病理的动物模型的出现，特别是胫骨高位截骨术(HTO)的大型模型的出现，使得识别此类事件(从而确定可能的治疗靶点)成为可能。从治疗的角度来看，间充质干细胞(MSCs)是治疗骨性关节炎的一种有前景的选择，并可与整合支架和药物/生长因子的功能替代物在组织工程中一起使用。总之，在骨性关节炎的基础和实验知识方面的这些进展可能允许产生改进的、适应的治疗方案来治疗人类骨性关节炎。
Osteoarthritis (OA) is a prevalent, disabling disorder of the joints that affects a large population worldwide and for which there is no definitive cure. This review provides critical insights into the basic knowledge on OA that may lead to innovative end efficient new therapeutic regimens. While degradation of the articular cartilage is the hallmark of OA, with altered interactions between chondrocytes and compounds of the extracellular matrix, the subchondral bone has been also described as a key component of the disease, involving specific pathomechanisms controlling its initiation and progression. The identification of such events (and thus of possible targets for therapy) has been made possible by the availability of a number of animal models that aim at reproducing the human pathology, in particular large models of high tibial osteotomy (HTO). From a therapeutic point of view, mesenchymal stem cells (MSCs) represent a promising option for the treatment of OA and may be used concomitantly with functional substitutes integrating scaffolds and drugs/growth factors in tissue engineering setups. Altogether, these advances in the fundamental and experimental knowledge on OA may allow for the generation of improved, adapted therapeutic regimens to treat human OA.