Perceptions of control and unrealistic optimism in early-phase cancer trials
Perceptions of control and unrealistic optimism in early-phase cancer trials
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DOI：
10.1136/medethics-2016-103724
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发表时间：
2018-02-01
影响因子：
4.1
通讯作者：
Sulmasy, Daniel P.
中科院分区：
文献类型：
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作者：
Jansen, Lynn A.;Mahadevan, Daruka;Sulmasy, Daniel P.
目的最近的研究发现，在早期肿瘤学试验中，患者-受试者之间存在不切实际的乐观（UO）。我们的目的是调查在这种情况下引起这种偏见的认知和动机因素。我们预计控制的看法是一个很强的相关性，不切实际的optimity.Methods的患者受试者参加了早期阶段的肿瘤学试验的研究在美国的两个网站进行。受访者完成了问卷调查，旨在评估不切实际的乐观主义和几个风险属性变量，已被发现引起的偏见在其他context.Results一百七十一患者同意接受采访，我们的研究。在所有9个研究相关问题中，发现了显著水平的感知可控性。控制的看法被发现预测不切实际的乐观。另外两个风险属性变量，指标意识（p=0.024）和心理形象（p=0.022），与不切实际的乐观。然而，在多元回归分析中，意识和心理形象退出了模型，感知可控性是唯一与不切实际的乐观独立相关的因素（p
Purpose Recent research has found unrealistic optimism (UO) among patient-subjects in early-phase oncology trials. Our aim was to investigate the cognitive and motivational factors that evoke this bias in this context. We expected perceptions of control to be a strong correlate of unrealistic optimism.Methods A study of patient-subjects enrolled in early-phase oncology trials was conducted at two sites in the USA. Respondents completed questionnaires designed to assess unrealistic optimism and several risk attribute variables that have been found to evoke the bias in other contexts.Results One hundred and seventy-one patient-subjects agreed to be interviewed for our study. Significant levels of perceived controllability were found with respect to all nine research-related questions. Perceptions of control were found to predict unrealistic optimism. Two other risk attribute variables, awareness of indicators (p=0.024) and mental image (p=0.022), were correlated with unrealistic optimism. However, in multivariate regression analysis, awareness and mental image dropped out of the model and perceived controllability was the only factor independently associated with unrealistic optimism (p