The effects of cold, rotation, and genotype on the production of ultrasonic calls in infant mice
The effects of cold, rotation, and genotype on the production of ultrasonic calls in infant mice
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DOI：
10.1023/a:1019728813891
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发表时间：
2002-07-01
影响因子：
2.6
通讯作者：
Schanz, N
中科院分区：
文献类型：
--
作者：
Hahn, ME;Schanz, N
最近，研究者们又重新对啮齿类动物的超声波叫声产生了兴趣，因为他们正在用它们来评估神经行为发育和焦虑的动物模型。我们比较了两种基因型的幼鼠在寒冷和旋转两种情况下的超声呼叫率。研究对象是来自29窝的169只小鼠幼崽，具有两种F-1基因型，C57 BL/10 J x DBA/2 J和C57 BL/10 J x SJL/J。每窝的一半在凉爽的情况下记录20秒，另一半在以10 rpm旋转20秒时记录。所有幼仔均在2 - 8日龄记录。旋转引起调用率约为凉爽的温度在每一天的年龄和平均跨天的两倍;情况（冷或旋转）占窝之间的变化超过50%。基因型也改变呼叫率，并在某些日子的情况和基因型相互作用。在神经行为发育和药物对幼鼠的影响的研究中，了解所用刺激和基因型的作用尤为重要。
There has been a revival of interest recently in the ultrasonic calls of infant rodents as investigators are using them to assess neurobehavioral development and animal models of anxiety. We compared the rates of ultrasonic calling of infant mice of two genotypes in two situations, cold and rotation. The subjects of study were 169 mouse pups from 29 litters and of two F-1 genotypes, C57BL/10J x DBA/2J and C57BL/10J x SJL/J. Half of each litter was recorded in a cool situation for 20 seconds and the other half was recorded while rotating at 10 rpm for 20 seconds. All pups were recorded on days of age 2 to 8. Rotation elicited calling at about twice the rate as cool temperature on each day of age and on average across days; situation (cold or rotation) accounted for over 50% of the variation between litters. Genotype also altered call rate, and on some days situation and genotype interacted. In studies of neurobehavioral development and the effects of pharmacological agents on infant mice, it is particularly important to understand the roles of the stimuli and genotypes employed.