The Association of Vitamin A and Vitamin D with Hypertension in Children: A Case-Control Study
The Association of Vitamin A and Vitamin D with Hypertension in Children: A Case-Control Study
复制标题
维生素 A 和维生素 D 与高血压的关系
DOI：
10.1155/2018/9295147
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发表时间：
2018-01-01
影响因子：
1.9
通讯作者：
Li，Tingyu
中科院分区：
文献类型：
--
作者：
Liang，Xiaohua;Chen，Min;Li，Tingyu
背景资料。儿童高血压患病率迅速上升。本研究旨在探讨维生素A、25(OH)D水平与儿童高血压的关系，并探讨儿童高血压的危险因素。纳入病例对照研究的儿童164名，年龄6~12岁，女性占49.39%。检测血清维生素A和25(OH)D水平、RARs和RXRs转录水平、25(OH)D受体和维生素A储存功能指标视黄醇酰基转移酶(LRAT)。高血压组血清维生素A水平与对照组无显著差异，但25(OH)D水平显著低于对照组(38.22±12.00umol/L vs.43.28±12.33umol/L，P=0.02)。高血压组RARα、RARβ和RARγ转录水平无明显差异，但LRAT低于对照组(P<；0.001)。高血压组儿童血浆25(OH)D受体水平低于对照组(P=0.003)。Logistic回归模型显示，LRAT、高密度脂蛋白、母乳喂养时间与血压呈负相关，腰围与血压呈正相关。LRAT、血清25(OH)D和25(OH)D受体与儿童血压水平显著相关，母乳喂养和高密度脂蛋白胆固醇是儿童血压水平的独立保护因素。
Background. The prevalence of hypertension in children increases rapidly. This paper is to investigate the association of vitamin A and serum 25(OH)D level with hypertension and to explore the risk factors of hypertension in children.Methods. 164 children (age: 6‐12 years, females: 49.39%) were included in this case‐control study. The serum vitamin A and serum 25(OH)D level, the transcription level of RARs and RXRs, 25(OH)D receptor, and the retinol acyltransferase (LRAT), an indicator of vitamin A storage function, were measured.Results. The serum vitamin A level in hypertensive subjects was not significantly different compared to control, but the serum 25(OH)D level was significantly lower in hypertensive subjects compared to control (38.22±12.00umol/L vs. 43.28±12.33 umol/L,P=0.02). The transcription levels of RARα, RARβ, and RARγwere not significantly different between the two groups; but the LRAT was lower in the hypertensive group than that in the control (P<0.001). Compared with control group, the level of 25(OH)D receptor was lower in hypertension children (P=0.003). Logistic regression model showed that LRAT, HDL, and breastfed duration were negatively associated with blood pressure, and waist circumference was positively associated with blood pressure.Conclusions. The LRAT, serum 25(OH)D, and 25(OH)D receptor were significantly associated with blood pressure level, and both breastfed and HDL‐C were independent protective factors of blood pressure level in children.