Seroimmunologic Classification of Chronic Hepatitis in 57 Children
Seroimmunologic Classification of Chronic Hepatitis in 57 Children
复制标题
57例儿童慢性肝炎的血清免疫学分类
作者：
M. Odiévre;G. Maggiore;J. Homberg;Fabrice Saadoun;A. Couroucé;Jeannine Yvart;M. Hadchouel;D. Alagille
本文对57例慢性肝炎患儿进行了血清免疫学检测。慢性迁延性肝炎21例，慢性活动性肝炎36例。治疗前采集血清标本进行乙肝表面抗原、抗-HBs、抗-HBc、平滑肌抗体和内质网抗体检测。21例慢性迁延性肝炎患者中有18例血清HBs Ag持续阳性。慢性活动性肝炎组根据乙肝病毒标志物阳性(7例)、平滑肌抗体阳性(10例)和内质网抗体阳性(9例)分为3个亚组。这些指标的测定可能有助于慢性肝炎患儿的分型。
A seroimmunologic evaluation of 57 children with chronic hepatitis is presented. Twenty‐one patients had chronic persistent hepatitis and 36 had chronic active hepatitis. Serum samples obtained before treatment were tested for HBsAg, anti‐HBs, anti‐HBc, smooth muscle antibody, and antibody to endoplasmic reticulum. A persistently positive HBsAg was observed in the serum of 18 of the 21 patients with chronic persistent hepatitis. The chronic active hepatitis group was divided into three subgroups according to the presence of hepatitis B‐virus markers (7 patients), smooth muscle antibody (10 patients), and endoplasmic reticulum antibody (9 patients). Determination of these markers could be useful for classifying children with chronic hepatitis.