Hospital Admissions and Chemical Composition of Fine Particle Air Pollution
Hospital Admissions and Chemical Composition of Fine Particle Air Pollution
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DOI：
10.1164/rccm.200808-1240oc
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发表时间：
2009-06-15
影响因子：
24.7
通讯作者：
Dominici, Francesca
中科院分区：
文献类型：
--
作者：
Bell, Michelle L.;Ebisu, Keita;Dominici, Francesca
理由：细颗粒物（PM2.5）对人类健康的短期影响存在无法解释的地理和季节差异。这一假说已经被提出，包括这种差异可能是由于PM2.5化学成分的变化，但支持这一假说的证据是lacked.Objectives：检查是否在住院的相对风险（RR）的变化与环境暴露于PM2.5总质量反映PM2.5化学成分的差异。我们按县和季节链接了两个国家数据集：（1）2000-2005年PM2.5化学成分的长期平均浓度;（2）与10 μ g/m2相关的65岁或以上人群心血管和呼吸系统住院的RR（3）1999年至2005年美国106个县同一天PM2.5总质量的增加。测量和主要结果：我们发现，PM2.5对心血管和呼吸系统住院治疗的短期影响的特定县估计值与特定县的钒，元素碳，或镍PM2.5含量。结论：社区与较高的PM2.5含量的镍，钒，元素碳和/或其相关来源被发现有较高的风险与短期暴露于PM2.5的住院治疗。
Rationale: There are unexplained geographical and seasonal differences in the short-term effects of fine particulate matter (PM2.5) on human health. The hypothesis has been advanced to include the possibility that such differences might be due to variations in the PM2.5 chemical composition, but evidence supporting this hypothesis is lacking.Objectives: To examine whether variation in the relative risks (RR) of hospitalization associated with ambient exposure to PM2.5 total mass reflects differences in PM2.5 chemical composition.Methods: We linked two national datasets by county and by season: (1) long-term average concentrations of PM2.5 chemical components for 2000-2005 and (2) RRs of cardiovascular and respiratory hospitalizations for persons 65 years or older associated with a 10-mu g/m(3) increase in PM2.5 total mass on the same day for 106 U.S. counties for 1999 through 2005.Measurements and Main Results: We found a positive and statistically significant association between county-specific estimates of the short-term effects of PM2.5 on cardiovascular and respiratory hospitalizations and county-specific levels of vanadium, elemental carbon, or nickel PM2.5 content.Conclusions: Communities with higher PM2.5 content of nickel, vanadium, and elemental carbon and/or their related sources were found to have higher risk of hospitalizations associated with short-term exposure to PM2.5.