Main actors behind the endometrial receptivity and successful implantation
Main actors behind the endometrial receptivity and successful implantation
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DOI：
10.1016/j.tice.2021.101656
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发表时间：
2021-10-08
期刊：
影响因子：
2.6
通讯作者：
Luddi, Alice
中科院分区：
文献类型：
--
作者：
Governini, Laura;Luongo, Francesca P.;Luddi, Alice
胚胎植入发生在月经周期的中期分泌期的一段短时间内，即植入窗口。在胚泡阶段，子宫内膜和胚胎之间的相互作用是成功着床的必要条件。迄今为止，还没有发现一种分子或受体在胚胎着床过程中起重要作用，但大量的介质，包括细胞因子、脂质、粘附分子、生长因子等，被报道支持妊娠的建立。因此，本文的目的不仅是描述参与着床过程的不同因素，而且试图描述这些因素之间的关系以及它们的时间调节激活。此外，将研究体外培养系统的可用性，以研究胚胎和子宫内膜之间的相互作用以及外泌体囊泡调节的旁分泌通讯，作为一种创新的方法，用于更精确地表征参与这一过程的不同分子之间的相互作用。对所有这些复杂机制的深入了解将有助于解决植入失败和不育的原因，从而为促进成功建立妊娠提供了新的途径。
Embryo implantation occurs during a short period of time, the implantation window, in the mid-secretory phase of the menstrual cycle. The cross-talk between the endometrium and the embryo, at the stage of blastocyst, is a necessary condition for successful implantation. Till now, no single molecule or receptor has been identified to play an essential role on embryo implantation but a huge number of mediators, including cytokines, lipids, adhesion molecules, growth factors, and others, are reported to support the establishment of pregnancy.Therefore, the aim of this review is not only to describe the different actors involved in the implantation process, but also to try to characterize the relationships between these factors as well as their time-regulated activation. Moreover, the availability of in vitro culture systems to study the interactions between embryo and endometrium as well as the paracrine communication regulated by exosomal vesicles will be investigated, as an innovative approach for a more precise characterization of the interactions between the different molecules involved in this process.The in-depth knowledge of all these complex mechanisms will allow to address the reasons of implantation failure and infertility, thus providing new avenues for promoting the successful establishment of a pregnancy.