Genetic correlational analysis of glycogen synthase kinase-3 beta and prepulse inhibition in inbred mice.
Genetic correlational analysis of glycogen synthase kinase-3 beta and prepulse inhibition in inbred mice.
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近交小鼠糖原合酶激酶 3 β 和前脉冲抑制的遗传相关分析。
DOI：
10.1111/j.1601-183x.2004.00065.x
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Agam,G
中科院分区：
文献类型：
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作者：
Amar,S;Jones,BC;Nadri,C;Kozlovsky,N;Belmaker,RH;Agam,G
在人类中，精神分裂症患者的GSK‐3β活性降低，脉冲前的惊吓反应（PPI）抑制也降低。我们在实验室对10个自交系小鼠品系进行了PPI值与额叶皮质GSK‐3活性的遗传相关性分析。该方法可为动物模型研究提供相关参数。事实上，我们通过两种不同的方法获得了酶活性和PPI之间的显著相关性。这可能表明，GSK‐3β调控的遗传学研究有望理解精神分裂症的一些生化基础。
In humans, GSK‐3β activity is diminished in schizophrenic patients as is prepulse inhibition of the startle response (PPI). We performed a genetic correlational analysis between published PPI values and frontal cortex GSK‐3 activity analyzed in our laboratory in 10 inbred mouse strains. This methodology could indicate relevant parameters for study in an animal model. Indeed, we obtained significant correlations between the enzyme's activity and PPI measured by two different methods. This may indicate that investigation of the genetics of GSK‐3β regulation holds promise for understanding some of the biochemical underpinnings of schizophrenia.