Obesity, type 2 diabetes, age, and female gender: significant risk factors in the development of alcoholic liver cirrhosis
Obesity, type 2 diabetes, age, and female gender: significant risk factors in the development of alcoholic liver cirrhosis
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DOI：
10.1007/s12072-012-9347-6
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发表时间：
2013-03-01
影响因子：
6.6
通讯作者：
Hibi, Toshifumi
中科院分区：
文献类型：
--
作者：
Horie, Yoshinori;Yamagishi, Yoshiyuki;Hibi, Toshifumi
最近的流行病学研究表明，酒精性肝硬化（ALC）继续增加，尽管自1999年以来酒精摄入量逐渐减少，这表明，还有其他的危险因素的发展ALC。一项全国性的调查，肝硬化（LC）通过要求主要医院机构提供2007年至2008年收治的LC患者人数及其病因，结果包括每日饮酒量、饮酒时间和其他相关人口统计学测量，女性ALC患者的饮酒量较低，饮酒时间较短。习惯性饮酒者（< 110 g/d）的糖尿病患病率高于重度饮酒者（110 g/d），分别为49.5%和20.3%（P < 0.001）。在男性ALC患者中，习惯性饮酒者的DM患病率较高，为55.2%，女性为20.6%（P < 0.001）。在体重指数为千分之一日元的患者中也观察到了同样的趋势25。习惯性饮酒者的肥胖患病率高于重度饮酒者，分别为49.7%和31.1%。超过90%的男性习惯性饮酒者患有糖尿病或肥胖，而不到一半的女性习惯性饮酒者有并发症。超过70%的男性患者年龄在60岁以上，肥胖、糖尿病、年龄和女性似乎是ALC的其他重要危险因素。我们的印象是，这些额外的风险因素可能有助于识别即使没有过量饮酒也可能进展为ALC的酒精中毒患者。
Recent epidemiological studies show that alcoholic liver cirrhosis (ALC) continues to increase in spite of a gradual decrease in the alcohol intake beyond 1999, indicating that there are other risk factors for the development of ALC.A nationwide survey of liver cirrhosis (LC) was undertaken by asking major hospital institutions to provide the number of patients with LC admitted between 2007 and 2008 together with their etiologic findings including the daily intake of alcohol, period of drinking, and other relevant demographic measurements.The intake of alcohol in female ALC patients was lower together with a shorter drinking period versus male patients. The prevalence of diabetes mellitus (DM) in ALC patients was higher in habitual drinkers (< 110 g/day) than in heavy drinkers (a parts per thousand yen110 g/day), 49.5 versus 20.3%, respectively (P < 0.001). In male ALC patients, the prevalence of DM was higher in habitual drinkers, 55.2 versus 20.6% for the female gender (P < 0.001). The same tendency was seen in patients with a body mass index a parts per thousand yen25. The prevalence of obesity was higher in habitual drinkers than in heavy drinkers, 49.7 versus 31.1%, respectively. More than 90% of the male habitual drinkers either had DM or were obese, whereas less than half of the female habitual drinkers had a concomitant complication. More than 70% of the male ALC patients were over 60 years.Obesity, DM, age, and female gender appear to be additional significant risk factors for ALC. Our impression is that these additional risk factors might help to identify alcoholic patients who may progress to ALC even without excessive alcohol intake.