Recent advances and limitations in the application of kahalalides for the control of cancer.
Recent advances and limitations in the application of kahalalides for the control of cancer.
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DOI：
10.1016/j.biopha.2022.112676
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发表时间：
2022-04
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影响因子：
--
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--
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自从1993年发现海洋缩肽的kahalalide家族以来，已经做了大量的工作来开发这些化合物作为新的和生物学上不同的抗癌剂。临床试验和实验室研究已经产生了大量的数据，表明健康细胞对卡哈拉内酯的耐受性和对病变细胞的选择性活性。目前，两种分子引起了最大程度的关注，即卡哈拉内酯F（KF）和异卡哈拉内酯F（isoKF，Irvalec，PM 02734，elisidepsin）。这两种化合物最初都是从sarcoglossan软体动物Elysia rufescens中分离出来的，但由于其独特的结构特征，人们推测这些分子的最终来源是微生物。寻找它们的真正来源一直是相当多的研究的主题，期望找到新的类似物和可培养的表达系统，该表达系统可以通过发酵产生足够的工业相关材料。
Since the discovery of the kahalalide family of marine depsipeptides in 1993, considerable work has been done to develop these compounds as new and biologically distinct anti-cancer agents. Clinical trials and laboratory research have yielded a wealth of data that indicates tolerance of kahalalides in healthy cells and selective activity against diseased cells. Currently, two molecules have attracted the greates level of attention, kahalalide F (KF) and isokahalalide F (isoKF, Irvalec, PM 02734, elisidepsin). Both compounds were originally isolated from the sarcoglossan mollusk Elysia rufescens but due to distinct structural characteristics it has been hypothesized and recently shown that the ultimate origin of the molecules is microbial. The search for their true source has been a subject of considerable research in the anticipation of finding new analogs and a culturable expression system that can produce sufficient material through fermentation to be industrially relevant.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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DOI：
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发表时间：
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期刊：
Breast cancer research : BCR
影响因子：
--
作者：
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通讯作者：
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