Elimination of piperacillin and tazobactam by renal replacement therapies with AN69 and polysulfone hemofilters:: Evaluation of the sieving coefficient
Elimination of piperacillin and tazobactam by renal replacement therapies with AN69 and polysulfone hemofilters:: Evaluation of the sieving coefficient
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DOI：
10.1159/000092921
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发表时间：
2006-01-01
影响因子：
3
通讯作者：
Pedraz, J. L.
中科院分区：
文献类型：
--
作者：
Arzuaga, A.;Isla, A.;Pedraz, J. L.
Background/Aim: Piperacillin-tazobactam is commonly used to treat infections in ICU patients. Controversial data have been published about the sieving/saturation coefficient (Sc/Sa) of piperacillin during continuous renal replacement therapies (CRRT). The objective was to evaluate the Sc/Sa of piperacillin-tazobactam during continuous venovenous hemofiltration (CVVH) and continuous venovenous hemodialysis (CVVHD) using AN69 and polysulfone. Methods: Ringer lactate, BSA-containing Ringer lactate and plasma were circulated at 150 ml/min. The ultrafiltrate/dialysis flow was kept at 1,500 ml/min. A bolus was injected and samples were taken. Drugs were measured using HPLC. Sc/Sa was calculated according to standard formula. Results: Free passage of drugs through the membranes was reported with protein free solutions. In the presence of proteins the Sc/Sa lowered and correlated to protein free fraction. Polysulfone had a significantly higher permeability than AN69 during CVVH. Conclusion: Drug binding to albumin contributes to the decrease of the Sc/Sa of piperacillin but it does not completely justify the in vivo value obtained by some authors. Copyright (c) 2006 S. Karger AG, Basel
