Ascorbic acid inhibits the squamous metaplasia that results from treatment of tracheal explants with asbestos or benzo[a]pyrene-coated asbestos.
Ascorbic acid inhibits the squamous metaplasia that results from treatment of tracheal explants with asbestos or benzo[a]pyrene-coated asbestos.
复制标题
抗坏血酸抑制鳞状化生，该鳞状化生是由用石棉或苯并[a]芘涂覆的石棉处理气管外植体引起的。
DOI：
10.1016/0304-3835(88)90234-0
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发表时间：
1988
期刊：
影响因子：
9.7
通讯作者：
Bresnick,E
中科院分区：
文献类型：
--
作者：
Holtz,G;Bresnick,E
在存在或不存在苯并[a]芘（BP）、青石棉或BP涂覆的青石棉的情况下，将气管外植体保持在培养物中。l-抗坏血酸和dl-α-生育酚对青石棉诱导的气管上皮化生有一定的保护作用。此外，抗坏血酸降低了暴露于BP-青石棉的仓鼠气管外植体中观察到的化生程度。
Hamster tracheal explants were maintained in culture in the presence or absence of benzo[a]pyrene (BP), crocidolite asbestos, or BP-coated crocidolite. Dose-dependent squamous metaplasia was observed in the treated samples.l-Ascorbic acid anddl-α-tocopherol were able to partially protect the tracheal explants from the metaplastic response induced by crocidolite. Furthermore, ascorbic acid reduced the extent of metaplasia observed in hamster tracheal explants that were exposed to BP-crocidolite.