Do we know anything about how left-right asymmetry is first established in the vertebrate embryo?
Do we know anything about how left-right asymmetry is first established in the vertebrate embryo?
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DOI：
10.1007/s10735-005-9000-y
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发表时间：
2005-06-01
影响因子：
3.2
通讯作者：
Tabin, C
中科院分区：
文献类型：
--
作者：
Tabin, C
我真的很喜欢节点流假说。每个人都喜欢节点流假说：一个对称的单纤毛场从节点腹侧底部的每个细胞中发芽，所有细胞都以相同的方向旋转，启动细胞外液体穿过节点的快速流动，从而打破了早期胚胎的两侧对称景观。这是一个优雅的解决方案，解决了一个智力上令人烦恼的问题，即对称性是如何在每个胚胎中以相同的方向被打破的，而不需要参考任何外部线索。它将许多以前无法解释的观察结果联系在一起。而且，当该模型首次引入文献时，它满足了怀疑论者提出的许多最初的关键测试。我们都愿意相信。但这是对的吗？
I really like the nodal flow hypothesis. Everyone likes the nodal flow hypothesis: a symmetric field of monocilia sprouting from each cell on the ventral floor of the node, all rotating in the same direction, setting in motion a leftward flow of extra-cellular fluid across the node, thereby breaking the bilaterally symmetric landscape of the early embryo. It is such an elegant solution to the intellectually vexing problem of how symmetry is consistently broken in the same orientation in each embryo without reference to any external cues. It ties together so many previously unexplained observations. And it has satisfied so many of the initial key tests skeptics proposed when the model was first introduced into the literature. We all want to believe it. But is it right?