Harnessing non-covalent interactions to exert control over regioselectivity and site-selectivity in catalytic reactions.
Harnessing non-covalent interactions to exert control over regioselectivity and site-selectivity in catalytic reactions.
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DOI：
10.1039/c6sc04157d
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发表时间：
2017-02-01
期刊：
影响因子：
8.4
通讯作者：
Phipps RJ
中科院分区：
文献类型：
--
作者：
Davis HJ;Phipps RJ
这一观点探讨了已经取得的进展，在使用非共价相互作用，以控制区域选择性和位点选择性催化。不对称催化已经被革命性地认识到，有吸引力的非共价相互作用，如氢键和离子对，可以作为强大的控制器的对映体选择性时，纳入适当的小分子手性支架。考虑到这些巨大的进步，令人惊讶的是，仍然有相对有限数量的非共价相互作用的例子被利用来控制催化中的区域选择性或位点选择性，这是合成化学家面临的另外两个基本选择性方面。这种观点探讨了迄今为止在这一领域取得的进展，使用非共价相互作用与过渡金属催化以及在纯有机催化剂的背景下。我们希望这将突出这种方法在设计选择性催化反应方面的巨大潜力。
This perspective examines the progress that has been made in using non-covalent interactions to control regioselectivity and site-selectivity in catalysis. Asymmetric catalysis has been revolutionised by the realisation that attractive non-covalent interactions such as hydrogen bonds and ion pairs can act as powerful controllers of enantioselectivity when incorporated into appropriate small molecule chiral scaffolds. Given these tremendous advances it is surprising that there are still a relatively limited number of examples of non-covalent interactions being harnessed for control of regioselectivity or site-selectivity in catalysis, two other fundamental selectivity aspects facing the synthetic chemist. This perspective examines the progress that has been made in this area thus far using non-covalent interactions in conjunction with transition metal catalysis as well as in the context of purely organic catalysts. We hope this will highlight the great potential in this approach for designing selective catalytic reactions.