Renal papillary calcification and the development of calcium oxalate monohydrate papillary renal calculi: a case series study.
Renal papillary calcification and the development of calcium oxalate monohydrate papillary renal calculi: a case series study.
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DOI：
10.1186/1471-2490-13-14
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发表时间：
2013-03-11
期刊：
影响因子：
2
通讯作者：
Servera A
中科院分区：
文献类型：
--
作者：
Grases F;Costa-Bauzá A;Prieto RM;Conte A;Servera A
本研究的目的是通过一系列病例（四名患者）确定肾乳头中的钙化沉积物与一水草酸钙 (COM) 乳头状结石的形成之间的关系。根据最近收集的乳头状结石，我们回顾性评估了接受逆行输尿管镜检查的 COM 乳头状结石患者。 COM 乳头状结石被发现是由上皮下损伤引起的。许多这些病变经历了羟基磷灰石（HAP）钙化，牙石形态和凹区中 HAP 的量取决于钙化损伤的位置。大多数 HAP 沉积物生长，侵蚀覆盖肾乳头的上皮，与尿液接触并开始形成 COM 结石。上皮下 HAP 斑块可能会改变覆盖乳头的上皮，导致 COM 晶体直接沉积在上皮上。组织钙化取决于预先存在的损伤，该过程的持续是由于调节剂和/或结晶抑制剂的缺乏。由于结石形态和检测到的 HAP 量取决于钙化损伤的位置和广泛程度，因此同一患者中可以发现所有类型的乳头状 COM 结石。所有患者均有上皮下钙化，乳头状结石较少，表明部分上皮下钙化没有进一步发展并被重吸收。大量的上皮下钙化增加了其中一些钙化转变为 COM 乳头状结石的可能性。
The objective of this study is to determine in a case series (four patients) how calcified deposits in renal papillae are associated with the development of calcium oxalate monohydrate (COM) papillary calculi. From the recently collected papillary calculi, we evaluated retrospectively patients, subjected to retrograde ureteroscopy, with COM papillary lithiasis. The COM papillary calculi were found to result from subepithelial injury. Many of these lesions underwent calcification by hydroxyapatite (HAP), with calculus morphology and the amount of HAP in the concave zone dependent on the location of the calcified injury. Most of these HAP deposits grew, eroding the epithelium covering the renal papillae, coming into contact with urine and starting the development of COM calculi. Subepithelial HAP plaques may alter the epithelium covering the papillae, resulting in the deposit of COM crystals directly onto the epithelium. Tissue calcification depends on a pre-existing injury, the continuation of this process is due to modulators and/or crystallization inhibitors deficiency. Since calculus morphology and the amount of detected HAP are dependent on the location and widespread of calcified injury, all types of papillary COM calculi can be found in the same patient. All patients had subepithelial calcifications, with fewer papillary calculi, demonstrating that some subepithelial calcifications did not further evolve and were reabsorbed. A high number of subepithelial calcifications increases the likelihood that some will be transformed into COM papillary calculi.
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影响因子：
5
作者：
Grases, F;Costa-Bauzá, A;Conte, A
通讯作者：
Conte, A
影响因子：
19.6
作者：
FINLAYSON, B
通讯作者：
FINLAYSON, B
影响因子：
4.5
作者：
Govindaraj, A;Selvam, R
通讯作者：
Selvam, R
影响因子：
3.1
作者：
Grases, F;Sanchis, P;Torres, JJ
通讯作者：
Torres, JJ
影响因子：
6.6
作者：
PRIEN, EL
通讯作者：
PRIEN, EL