Hydrogels as a platform for stem cell delivery to the heart.
Hydrogels as a platform for stem cell delivery to the heart.
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DOI：
10.1111/j.1751-7133.2010.00145.x
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发表时间：
2010-05
期刊：
影响因子：
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通讯作者：
Booz GW
中科院分区：
文献类型：
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作者：
Kurdi M;Chidiac R;Hoemann C;Zouein F;Zgheib C;Booz GW
干细胞疗法为修复受伤或衰竭的心脏提供了巨大的希望。然而，迄今为止的临床试验结果表明，实际实现的效益远远低于承诺。许多因素可以解释为什么会出现这种情况，但在受损心脏的恶劣环境中干细胞保留和植入不良似乎是一个主要因素。改善干细胞的保留和交付后的寿命似乎是增强其修复功能的合理方法。实现这一目标的一种方法可能是可注射水凝胶，它可以将干细胞固定在适当的位置，同时提供庇护环境。水凝胶还提供了一种方法，允许封装的干细胞产生的旁分泌因子扩散到受损的心肌中。或者，水凝胶本身可用于持续递送修复因子。在这里我们讨论基于壳聚糖的水凝胶。
Stem cell therapy offers great promise to repair the injured or failing heart. The outcomes of clinical trials to date, however, have shown that the actual benefit realized falls far short of the promise. A number of factors may explain why that is the case, but poor stem cell retention and engraftment in the hostile environment of the injured heart would seem to be a major factor. Improving stem cell retention and longevity once delivered would seem a logical means to enhance their reparative function. One way to accomplish this goal may be injectable hydrogels, which would serve to fix stem cells in place while providing a sheltering environment. Hydrogels also provide a means to allow for the paracrine factors produced by encapsulated stem cells to diffuse into the injured myocardium. Alternatively, hydrogels themselves can be used for the sustained delivery of reparative factors. Here we discuss chitosan-based hydrogels.