Recruiting Intergenerational African American Males for Biomedical Research Studies: A Major Research Challenge
Recruiting Intergenerational African American Males for Biomedical Research Studies: A Major Research Challenge
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DOI：
10.1016/s0027-9684(15)30361-8
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发表时间：
2011-06-01
影响因子：
3.3
通讯作者：
Pericak-Vance, Margaret
中科院分区：
文献类型：
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作者：
Byrd, Goldie S.;Edwards, Christopher L.;Pericak-Vance, Margaret
所有个人的健康和福祉，无论种族、民族或性别如何，都是一个重大的公共卫生问题。尽管少数民族的健康状况有了许多改善，但非洲裔美国男性的年龄调整死亡率仍然是美国任何种族性别群体中最高的。造成这种差距的原因是糖尿病、人体免疫缺陷病毒（艾滋病毒）、癌症和心血管疾病等疾病造成的死亡，以及许多历史和当前的社会和文化结构阻碍了更好的健康成果。对医学界的不信任、教育不足、社会经济地位低、社会剥夺和初级卫生保健服务利用不足，都导致非裔美国人与高加索人相比，健康和卫生保健结果不成比例。由于大多数生物医学研究和临床试验中存在常见的抽样误差，对非裔美国人男性影响不成比例的疾病的临床研究结果的可靠性往往有限。非裔美国男性在临床试验中代表性不足的原因有很多，包括他们对少数民族遭受虐待或遭受种族歧视或种族主义挑衅的相关历史生物医学事件的共同回忆和解释。此外，与白人男性和女性以及非裔美国女性相比，非裔美国男性的受教育程度仍然较低，在社会中被剥夺的权利更多。因此，了解他们对健康和参与研究的障碍的看法，即使是在早期发育阶段，也很重要。在努力了解他们的参与水平，参与动机，教育的影响，并参与研究的观点，本研究旨在探讨影响他们的参与意愿的因素。我们的研究表明：（1）所有年龄段的非裔美国男性都愿意参加几种类型的研究，即使是那些需要人体样本的研究;（2）他们的参与程度受到教育水平的显著影响;（3）他们决定参加研究是出于公民责任，金钱补偿，以及他们或亲属是否患有感兴趣的疾病。然而，所有年龄组的非裔美国男性继续报告缺乏信任是他们不愿意参与生物医学研究的主要原因。有一个持续的需要继续寻求建议，改善沟通，并设计研究，赢得信任，提高参与非洲裔美国男性作为一个目标的代表性不足的人口。这种沟通和对话应该发生在研究发展的所有年龄层次，以评估当前的态度和行为的非洲裔美国男性周围的参与。
The health and well-being of all individuals, independent of race, ethnicity, or gender, is a significant public health concern. Despite many improvements in the status of minority health, African American males continue to have the highest age-adjusted mortality rate of any race-sex group in the United States. Such disparities are accounted for by deaths from a number of diseases such as diabetes, human immunodeficiency virus (HIV), cancer, and cardiovascular disease, as well as by many historical and present social and cultural constructs that present as obstacles to better health outcomes. Distrust of the medical community, inadequate education, low socioeconomic status, social deprivation, and underutilized primary health care services all contribute to disproportionate health and health care outcomes among African Americans compared to their Caucasian counterparts. Results of clinical research on diseases that disproportionately affect African American males are often limited in their reliability due to common sampling errors existing in the majority of biomedical research studies and clinical trials. There are many reasons for underrepresentation of African American males in clinical trials, including their common recollection and interpretation of relevant historical of biomedical events where minorities were abused or exposed to racial discrimination or racist provocation. In addition, African American males continue to be less educated and more disenfranchised from the majority in society than Caucasian males and females and their African American female counterparts. As such, understanding their perceptions, even in early developmental years, about health and obstacles to involvement in research is important. In an effort to understand perspectives about their level of participation, motivation for participation, impact of education, and engagement in research, this study was designed to explore factors that impact their willingness to participate. Our research suggests that: (1) African American males across all ages are willing to participate in several types of research studies, even those that require human samples; (2) their level of participation is significantly influenced by education level; and (3) their decision to participate in research studies is motivated by civic duty, monetary compensation, and whether they or a relative has had the disease of interest. However, African American males, across all age groups, continue to report a lack of trust as a primary reason for their unwillingness to participate in biomedical research. There is an ongoing need to continue to seek advice, improve communication, and design research studies that garner trust and improve participation among African American males as a targeted underrepresented population. Such communication and dialogues should occur at all age levels of research development to assess current attitudes and behaviors of African American males around participation.