Medium-Chain Triglyceride Activated Brown Adipose Tissue and Induced Reduction of Fat Mass in C57BL/6J Mice Fed High-fat Diet
Medium-Chain Triglyceride Activated Brown Adipose Tissue and Induced Reduction of Fat Mass in C57BL/6J Mice Fed High-fat Diet
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DOI：
10.3967/bes2015.012
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发表时间：
2015-02-01
影响因子：
3.5
通讯作者：
Xue Chang Yong
中科院分区：
文献类型：
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作者：
Zhang Yong;Xu Qing;Xue Chang Yong
目的探讨中链甘油三酯（MCT）对棕色脂肪组织（BAT）的激活作用。方法30只雄性C57 BL/6 J肥胖小鼠随机分为2组，分别给予2%MCT和长链甘油三酯（LCT）。体重、血液生化变量、肩胛间棕色脂肪组织（IBAT）质量、β 3-肾上腺素能受体的mRNA和蛋白表达（β 3-AR）、解偶联蛋白-1（UCP 1）、激素敏感脂肪酶（HSL）、蛋白激酶A（PKA），脂肪甘油三酯脂肪酶（ATGL）结果与LCT组相比，MCT组体重和体脂量明显降低（P
Objective To investigate activation of brown adipose tissue (BAT) stimulated by medium-chain triglyceride (MCT).Methods 30 Male C57BL/6J obese mice induced by fed high fat diet (HFD) were divided into 2 groups, and fed another HFD with 2% MCT or long-chain triglyceride (LCT) respectively for 12 weeks. Body weight, blood biochemical variables, interscapular brown fat tissue (IBAT) mass, expressions of mRNA and protein of beta 3-adrenergic receptors (beta 3-AR), uncoupling protein-1 (UCP1), hormone sensitive lipase (HSL), protein kinase A (PKA), and adipose triglyceride lipase (ATGL) in IBAT were measured.Results Significant decrease in body weight and body fat mass was observed in MCT group as compared with LCT group (P