The Diagnostic Values of Ultrasound and Ultrasound-Guided Fine Needle Aspiration in Subcentimeter-Sized Thyroid Nodules
The Diagnostic Values of Ultrasound and Ultrasound-Guided Fine Needle Aspiration in Subcentimeter-Sized Thyroid Nodules
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DOI：
10.1245/s10434-011-1813-1
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发表时间：
2012-01-01
影响因子：
3.7
通讯作者：
Kwak, Jin Young
中科院分区：
文献类型：
--
作者：
Moon, Hee Jung;Son, Eunju;Kwak, Jin Young
2006年4月至2006年12月，对1403例(平均49.3岁，10~84岁)甲状腺结节行超声检查和超声引导下细针抽吸(US-FNA)检查。使用Cochran-Armitage趋势检验和多变量Logistic回归分析来研究结节大小与标本不足之间的关系。为了评估US和US-FNA的诊断性能，我们选择了852个接受手术、随访US-FNA或随访US的结节。受试者工作特征(ROC)曲线分析用于确定US和US-FNA的准确性。在1440个结节中，256个(17.8%)产生的标本不充分。随着结节大小的增加，标本不足的比率降低(P<；0.001)。大小为6 mm的标本在不足和足够样本之间显示出统计学意义(P<；0.001)。超声诊断准确率随结节大小增加略有提高。6 mm以下的结节超声检查假阳性率高于<6 mm结节(P=0.049)。然而，US-FNA在所有标本充足的结节中表现出很高的诊断性能。随着结节大小的减小，US-FNA标本不足和US检查的假阳性增加。然而，假设标本充足，US-FNA显示了良好的诊断准确性。
The diagnostic performances of ultrasound (US) examination and US-guided fine needle aspiration (US-FNA) were investigated in thyroid nodules a parts per thousand currency sign10 mm in size.From April 2006 to December 2006, 1440 nodules a parts per thousand currency sign10 mm in size in 1403 patients (mean age, 49.3 years; range, 10-84 years) underwent US and US-FNA. The association between nodule size and inadequate specimen was investigated using the Cochran-Armitage trend test and multivariate logistic regression analysis. To evaluate the diagnostic performances of US and US-FNA, we selected 852 nodules that had undergone surgery, follow-up US-FNA, or follow-up US. A receiver operating characteristic (ROC) curve analysis was used to determine the accuracies of US and US-FNA.Of 1440 nodules, 256 (17.8%) yielded inadequate specimens. As the nodule size increased, the rate of inadequate specimens decreased (P < 0.001). A size of 6 mm demonstrated statistical significance between inadequate and adequate specimens (P < 0.001). The diagnostic accuracy of US was slightly improved as nodule size increased. The false positive rate of US examination was higher in nodules a parts per thousand currency sign6 mm compared with that of nodules > 6 mm in size (P = 0.049). However, US-FNA demonstrated high diagnostic performance in all nodules with adequate specimen.The inadequate specimens of US-FNA and false positives for US examinations increased as nodule size decreased. However, US-FNA demonstrated good diagnostic accuracy, assuming the specimen was adequate.