Soy protein isolate increases urinary Estrogens and the ratio of 2:16α-hydroxyestrone in men at high risk of prostate cancer
Soy protein isolate increases urinary Estrogens and the ratio of 2:16α-hydroxyestrone in men at high risk of prostate cancer
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DOI：
10.1093/jn/137.10.2258
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发表时间：
2007-10-01
影响因子：
4.2
通讯作者：
Kurzer, Mindy S.
中科院分区：
文献类型：
--
作者：
Hamilton-Reeves, Jill M.;Rebello, Salome A.;Kurzer, Mindy S.
特定的雌激素代谢物可能引发和促进乳腺癌相关的癌症。在流行病学研究中，与对照组相比，前列腺癌病例中尿雌二醇（E2）的排泄量显著降低，尿2-羟基雌激素与16 α-羟基雌酮（2：16 OH-E1）的比值也较低。虽然大豆补充剂已被证明可以增加女性2：16 OH-E1的比例，但据我们所知，没有研究调查大豆补充剂对男性雌激素代谢的影响。这项随机对照试验的目的是确定大豆分离蛋白消费对发展为晚期前列腺癌的高危男性雌激素代谢的影响。58名男性在他们的日常饮食中添加了3种蛋白分离物：1）富含大豆异黄酮的大豆分离蛋白（SPI+）（107 mg大豆异黄酮/d）; 2）酒精洗涤的大豆分离蛋白（SPI-）（
Specific estrogen metabolites may initiate and promote hormone-related cancers. In epidemiological studies, significantly lower excretion of urinary estradiol (E2) and lower ratio of urinary 2-hydroxy estrogens to 16 alpha-hydroxyestrone (2:16 OH-E1) have been reported in prostate cancer cases compared to controls. Although soy supplementation has been shown to increase the ratio 2:16 OH-E1 in women, no studies to our knowledge have investigated the effects of soy supplementation on estrogen metabolism in men. The objective of this randomized controlled trial was to determine the effects of soy protein isolate consumption on estrogen metabolism in men at high risk for developing advanced prostate cancer. Fifty-eight men supplemented their habitual diets with I of 3 protein isolates: 1) isoflavone-rich soy protein isolate (SPI+) (107 mg isoflavones/d); 2) alcohol-washed soy protein isolate SPI-) (