Cyclodextrin Complexed [60]Fullerene Derivatives with High Levels of Photodynamic Activity by Long Wavelength Excitation.
Cyclodextrin Complexed [60]Fullerene Derivatives with High Levels of Photodynamic Activity by Long Wavelength Excitation.
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环糊精通过长波长激发复合具有高水平光动力活性的[60]富勒烯衍生物。
DOI：
10.1021/ml4001535
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发表时间：
2013
影响因子：
4.2
通讯作者：
Shiozaki K
中科院分区：
文献类型：
--
作者：
Ikeda A;Iizuka T;Maekubo N;Aono R;Kikuchi J;Akiyama M;Konishi T;Ogawa T;Ishida-Kitagawa N;Tatebe H;Shiozaki K
我们评估了C60衍生物·γ-环糊精（γ-CDx）复合物的光动力活性，并证明它们在长波长（610-720 nm）光照射下显着高于原始C60和C70·γ-CDx复合物，这代表了光动力治疗（PDT）的最佳波长。特别是，阳离子C60衍生物·γ-CDx复合物具有最高的光动力能力，因为该复合物具有产生高水平的1O2的能力并提供更高水平的细胞内摄取。该复合物的光动力活性大于光敏素，光敏素是已知临床光敏剂中使用最广泛的。因此，这些发现为优化 PDT 富勒烯衍生物合成的分子设计策略提供了重要信息。
We have evaluated the photodynamic activities of C60derivative·γ-cyclodextrin (γ-CDx) complexes and demonstrated that they were significantly higher than those of the pristine C60and C70·γ-CDx complexes under photoirradiation at long wavelengths (610–720 nm), which represent the optimal wavelengths for photodynamic therapy (PDT). In particular, the cationic C60derivative·γ-CDx complex had the highest photodynamic ability because the complex possessed the ability to generate high levels of1O2and provided a higher level of intracellular uptake. The photodynamic activity of this complex was greater than that of photofrin, which is the most widely used of the known clinical photosensitizers. These findings therefore provide a significant level of information toward the optimization of molecular design strategies for the synthesis of fullerene derivatives for PDT.