Conditions for fibronectin fibril formation in the early Xenopus embryo

Conditions for fibronectin fibril formation in the early Xenopus embryo
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早期爪蟾胚胎中纤连蛋白原纤维形成的条件

DOI:
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发表时间:
1998
影响因子:
2.5
通讯作者:
R. Winklbauer
R. Winklbauer
中科院分区:
生物学3区
文献类型:
--
作者:
R. Winklbauer

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Fibronectin fibril formation on a multilayered cohesive cell sheet is studied in the Xenopus embryo. In the blastula, secreted fibronectin accumulates in the blastocoel, where it associates with mucous material. At the onset of gastrulation, a fibrillar fibronectin matrix develops on the blastocoel roof. Cells engage in this process stochastically within a 2‐hr period. Fibril network formation requires more than 60 μg/ml of fibronectin, but the timing of fibrillogenesis is not regulated through the availability of fibronectin. With the exception of a few isolated mesoderm cells, only the cells of the blastocoel roof are able to form fibronectin fibrils. However, this requires that cells are provided with a free surface and, at the same time, with lateral adhesive cell contacts, i.e. fibril assembly occurs only on the surface of cohesive cells aggregates. This explains the observed restriction of fibronectin matrix formation to the inner surface of the blastocoel roof in the embryo. In addition, a minimum blastocoel roof size is required for fibril formation. Dev. Dyn. 1998;212:335–345. © 1998 Wiley‐Liss, Inc.
整合素依赖性粘附活性在原肠胚形成时由感应信号在空间上控制。
DOI: 10.1242/dev.122.9.2873
发表时间: 1996
期刊: Development (Cambridge, England)
影响因子: --
作者:
Ramos,JW;Whittaker,CA;DeSimone,DW
通讯作者: DeSimone,DW
纤连蛋白自缔合是由分子氨基末端三分之一内的互补位点介导的。
DOI: --
发表时间: 1994
期刊: The Journal of biological chemistry
影响因子: --
作者:
Aguirre,KM;McCormick,RJ;Schwarzbauer,JE
通讯作者: Schwarzbauer,JE
纤连蛋白的细胞粘附结构域和氨基末端基质组装结构域参与其组装成成纤维细胞细胞周基质。
DOI: --
发表时间: 1987
期刊: The Journal of biological chemistry
影响因子: --
作者:
McDonald,JA;Quade,BJ;Broekelmann,TJ;LaChance,R;Forsman,K;Hasegawa,E;Akiyama,S
通讯作者: Akiyama,S
DOI: 10.1006/dbio.1996.0174
发表时间: 1996-08-01
影响因子: 2.7
作者:
Winklbauer, R;Keller, RE
通讯作者: Keller, RE
结合纤连蛋白基质组装域的细胞表面分子。
DOI: --
发表时间: 1991
期刊: The Journal of biological chemistry
影响因子: --
作者:
Limper,AH;Quade,BJ;LaChance,RM;Birkenmeier,TM;Rangwala,TS;McDonald,JA
通讯作者: McDonald,JA