Conditions for fibronectin fibril formation in the early Xenopus embryo
Conditions for fibronectin fibril formation in the early Xenopus embryo
复制标题
早期爪蟾胚胎中纤连蛋白原纤维形成的条件
DOI:
--
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发表时间:
1998
影响因子:
2.5
通讯作者:
R. Winklbauer
中科院分区:
文献类型:
--
作者:
R. Winklbauer
Fibronectin fibril formation on a multilayered cohesive cell sheet is studied in the Xenopus embryo. In the blastula, secreted fibronectin accumulates in the blastocoel, where it associates with mucous material. At the onset of gastrulation, a fibrillar fibronectin matrix develops on the blastocoel roof. Cells engage in this process stochastically within a 2‐hr period. Fibril network formation requires more than 60 μg/ml of fibronectin, but the timing of fibrillogenesis is not regulated through the availability of fibronectin. With the exception of a few isolated mesoderm cells, only the cells of the blastocoel roof are able to form fibronectin fibrils. However, this requires that cells are provided with a free surface and, at the same time, with lateral adhesive cell contacts, i.e. fibril assembly occurs only on the surface of cohesive cells aggregates. This explains the observed restriction of fibronectin matrix formation to the inner surface of the blastocoel roof in the embryo. In addition, a minimum blastocoel roof size is required for fibril formation. Dev. Dyn. 1998;212:335–345. © 1998 Wiley‐Liss, Inc.
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DOI:
10.1242/dev.122.9.2873
发表时间:
1996
期刊:
Development (Cambridge, England)
影响因子:
--
作者:
Ramos,JW;Whittaker,CA;DeSimone,DW
通讯作者:
DeSimone,DW
DOI:
--
发表时间:
1994
期刊:
The Journal of biological chemistry
影响因子:
--
作者:
Aguirre,KM;McCormick,RJ;Schwarzbauer,JE
通讯作者:
Schwarzbauer,JE
DOI:
--
发表时间:
1987
期刊:
The Journal of biological chemistry
影响因子:
--
作者:
McDonald,JA;Quade,BJ;Broekelmann,TJ;LaChance,R;Forsman,K;Hasegawa,E;Akiyama,S
通讯作者:
Akiyama,S
影响因子:
2.7
作者:
Winklbauer, R;Keller, RE
通讯作者:
Keller, RE
DOI:
--
发表时间:
1991
期刊:
The Journal of biological chemistry
影响因子:
--
作者:
Limper,AH;Quade,BJ;LaChance,RM;Birkenmeier,TM;Rangwala,TS;McDonald,JA
通讯作者:
McDonald,JA