Regenerable Dihydrophenanthridine via Borane-Catalyzed Hydrogenation for the Asymmetric Transfer Hydrogenation of Benzoxazinones
Regenerable Dihydrophenanthridine via Borane-Catalyzed Hydrogenation for the Asymmetric Transfer Hydrogenation of Benzoxazinones
复制标题
通过硼烷催化氢化可再生二氢菲啶用于苯并恶嗪酮的不对称转移氢化
DOI：
10.1021/acs.orglett.2c01314
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发表时间：
2022-05-27
期刊：
影响因子：
5.2
通讯作者：
Du, Haifeng
中科院分区：
文献类型：
--
作者：
Gao, Bochao;Meng, Wei;Du, Haifeng
成功实现了H2下苯并恶嗪酮与手性磷酸的高度对映选择性转移氢化，其中硼烷促进了菲啶的氢化，从而再生了作为氢供体的二氢菲啶。以高达 99% ee 的高收率获得了多种二氢苯并恶嗪酮。目前的工作为受挫的路易斯对催化不对称氢化反应的非反应底物提供了一种有前途的解决方案。
The highly enantioselective transfer hydrogenation of benzoxazinones with chiral phosphoric acids under H2 was successfully achieved, where boranes promoted the hydrogenation of phenanthridine for the regeneration of dihydrophenanthridine as the hydrogen donor. A variety of dihydrobenzoxazinones were obtained in high yields with up to 99% ee. The current work provides a promising solution to unreactive substrates for frustrated Lewis pair-catalyzed asymmetric hydrogenation.