Relationship between FDG-PET and the immune microenvironment in breast cancer
Relationship between FDG-PET and the immune microenvironment in breast cancer
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DOI：
10.1016/j.ejrad.2022.110661
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发表时间：
2022-12-20
影响因子：
3.3
通讯作者：
Miyoshi, Yasuo
中科院分区：
文献类型：
--
作者：
Kitajima, Kazuhiro;Higuchi, Tomoko;Miyoshi, Yasuo
目的：探讨氟脱氧葡萄糖（FDG）摄取与（最大标准化摄取值[SUVmax]）和免疫标志物（肿瘤浸润淋巴细胞[TIL]和嗜中性粒细胞与淋巴细胞比率[NLR]），并评估任何相关性的潜在预后价值。数据来自502例乳腺癌患者，包括346例雌激素受体（ER）阳性/人表皮生长因子受体2（HER 2）阴性，88例HER 2阳性和68例三阴性病例接受了手术。使用考克斯比例风险模型和对数秩检验评估所有患者和每种亚型的临床病理因素、SUVmax、TILs、NLR、无复发生存期（RFS）和总生存期之间的关系。结果：高SUVmax与高TIL显著相关（p < 0.0001）。在低TIL（TILs 1）组中，高SUVmax（>= 3.585）患者的RFS显著短于低SUVmax（
Objective: To investigate the relationship between fluorodeoxyglucose (FDG) uptake (maximum standardised uptake value [SUVmax]) and immune markers (tumour-infiltrating lymphocytes [TILs] and neutrophil-to-lymphocyte ratio [NLR]) and evaluate the potential prognostic value of any correlations.Methods: Data from 502 patients with breast cancer, including 346 oestrogen receptor (ER)-positive / human epidermal growth factor receptor 2 (HER2)-negative, 88 HER2-positive, and 68 triple-negative cases, who had undergone surgery were reviewed. Relationships between the clinicopathological factors, SUVmax, TILs, NLR, recurrence-free survival (RFS), and overall survival of all patients and each subtype were evaluated using a Cox proportional hazards model and log-rank test. A sub-analysis of patients divided into low and high TIL groups was also undertaken.Results: High SUVmax was significantly related to high TILs (p < 0.0001). In low TIL (TILs1) group, patients with high SUVmax (>= 3.585) had a significantly shorter RFS than those with low SUVmax (