Fluorescent probes for the selective detection of chemical species inside mitochondria
Fluorescent probes for the selective detection of chemical species inside mitochondria
复制标题
用于选择性检测线粒体内化学物质的荧光探针
DOI：
10.1039/c5cc09248e
复制
发表时间：
2016-01-01
影响因子：
4.9
通讯作者：
Xu, Lin
中科院分区：
文献类型：
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作者：
Xu, Zheng;Xu, Lin
近年来，用于选择性检测线粒体内化学物种的新型荧光探针的制备引起了人们的极大关注，因为它们在化学、生物学和医学科学中有着广泛的应用。这篇专题文章重点介绍了这类荧光探针的设计原理和识别机制的最新进展。此外，还讨论了它们在检测线粒体中的活性氧物种(ROS)、一氧化氮、活性硫物种(RSS)、硫氧还蛋白(TRX)、金属离子、阴离子等方面的应用。
During the last few years, the preparation of novel fluorescent probes for the selective detection of chemical species inside mitochondria has attracted considerable attention because of their wide applications in chemistry, biology, and medical science. This feature article focuses on the recent advances in the design principles and recognition mechanisms of these kinds of fluorescent probes. In addition, their applications for the detection of reactive oxygen species (ROS), nitric oxide, reactive sulfur species (RSS), thioredoxin (Trx), metal ions, anions, etc. in the mitochondrion is discussed as well.