Water-Soluble N-Heterocyclic Carbene-Protected Gold Nanoparticles: Size-Controlled Synthesis, Stability, and Optical Properties
Water-Soluble N-Heterocyclic Carbene-Protected Gold Nanoparticles: Size-Controlled Synthesis, Stability, and Optical Properties
复制标题
DOI：
10.1002/anie.201701605
复制
发表时间：
2017-05-22
影响因子：
16.6
通讯作者：
Crudden, Cathleen M.
中科院分区：
文献类型：
--
作者：
Salorinne, Kirsi;Man, Renee W. Y.;Crudden, Cathleen M.
NHC-Au-I 复合物用于制备稳定的、水溶性的、NHC 保护的金纳米颗粒。纳米颗粒的水溶性、带电性质允许通过聚丙烯酰胺凝胶电泳 (PAGE) 进行分析，结果表明纳米颗粒具有高度单分散性，根据合成条件，其核心直径在 2.0 至 3.3 nm 之间可调。纳米颗粒的时间、热和化学稳定性被确定为高。 24小时后，用硫醇处理引起颗粒蚀刻；然而，较大的等离子体粒子对硫醇处理表现出更大的抵抗力。这些水溶性、生物相容性纳米颗粒是用于光声成像的有希望的候选者，即使是最小的纳米颗粒也能提供可靠的光声信号。
NHC-Au-I complexes were used to prepare stable, water-soluble, NHC-protected gold nanoparticles. The water-soluble, charged nature of the nanoparticles permitted analysis by polyacrylamide gel electrophoresis (PAGE), which showed that the nanoparticles were highly monodisperse, with tunable core diameters between 2.0 and 3.3 nm depending on the synthesis conditions. Temporal, thermal, and chemical stability of the nanoparticles were determined to be high. Treatment with thiols caused etching of the particles after 24 h; however larger plasmonic particles showed greater resistance to thiol treatment. These water-soluble, bio-compatible nanoparticles are promising candidates for use in photoacoustic imaging, with even the smallest nanoparticles giving reliable photoacoustic signals.