Dorsal and ventral visual stream contributions to preserved reading ability in patients with central alexia
Dorsal and ventral visual stream contributions to preserved reading ability in patients with central alexia
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DOI：
10.1016/j.cortex.2018.06.003
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发表时间：
2018-09-01
期刊：
影响因子：
3.6
通讯作者：
Leff, Alexander P.
中科院分区：
文献类型：
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作者：
Aguilar, Oscar M.;Kerry, Sheila J.;Leff, Alexander P.
我们调查了 23 名中枢性失读症 (CA) 患者的左颞顶叶区在支持阅读能力方面的作用。对于行为数据，我们采用主成分分析（PCA），它确定了两个组成部分：“大声朗读”和“阅读意义”。基于体素的 PCA 结果显示，朗读与左侧边缘上回（背侧视觉流的一部分）灰质密度之间存在关联。相比之下，阅读意义与左腹侧视觉流中的一个大簇相关，从侧副沟到前颞极。大多数峰值位于组病变图内，表明保留这些区域可以更好地保留阅读能力。然而，枕颞叶内侧的一处白质 (WM) 簇位于病变区域之外。事后测试表明，这里的 WM 密度与对照组相当，表明这不是由病变效应驱动的。对于这种相关性，两种最可能的解释是：1）病前的个体间大脑结构差异减轻了 CA 的影响； 2）病后以阅读为基础的实践导致了补偿可塑性。我们希望通过该队列中收集的纵向治疗数据来裁决这些解释。 (C) 2018 Elsevier Ltd. 保留所有权利。
We investigated the role of the left temporo-parietal regions in supporting reading abilities of 23 patients with central alexia (CA). For the behavioural data, we employed principal components analysis (PCA), which identified two components: 'reading aloud' and 'reading for meaning'. Voxel-based morphometry of the PCA results showed an association between reading aloud and grey matter density in the left supramarginal gyrus, part of the dorsal visual stream. By contrast, reading for meaning was associated with a large cluster in the left ventral visual stream, from the collateral sulcus to the anterior temporal pole.Most of the peaks were within the group lesion map, indicating that sparing of these areas results in better preservation of reading ability. However, one white matter (WM) cluster in the medial occipitotemporal lobe was outside the lesioned area. A post-hoc test demonstrated that WM density here was equivalent to controls, suggesting that this was not driven by lesion effects. The two likeliest explanations for this correlation are: 1) that pre-morbid, inter-individual differences in brain structure mitigate the effects of CA; 2) that post-morbid practice-based with reading caused compensatory plasticity. We hope to adjudicate between these explanations with longitudinal therapy data collected in this cohort. (C) 2018 Elsevier Ltd. All rights reserved.