Adiponectin as a biomarker of systemic inflammatory response in smoker patients with stable and exacerbation phases of chronic obstructive pulmonary disease
Adiponectin as a biomarker of systemic inflammatory response in smoker patients with stable and exacerbation phases of chronic obstructive pulmonary disease
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DOI：
10.1080/00365510802474400
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发表时间：
2009-01-01
影响因子：
2.1
通讯作者：
Karadag, Fisun
中科院分区：
文献类型：
--
作者：
Kirdar, Sevin;Serter, Mukadder;Karadag, Fisun
背景和目的。脂联素是一种脂肪组织来源的特异性蛋白质，具有能量稳态的作用，对胰岛素抵抗和动脉粥样硬化的发展具有保护作用，并具有抗炎特性。探讨慢性阻塞性肺疾病(COPD)患者血清脂联素作为全身炎症反应的生物标志物及其与瘦素、C反应蛋白(CRP)、血沉(ESR)和一氧化氮(NO)的关系。材料和方法。我们研究了36名男性COPD患者(15名稳定，21名恶化)和17名年龄和性别匹配的健康受试者。采用酶联免疫吸附试验检测脂联素和瘦素水平。采用散射比浊法测定血清CRP水平。血沉测定采用Westgren法，NO测定采用镉还原法。结果。COPD患者血清脂联素水平显著高于对照组(P<0.001)，而瘦素和NO水平无明显差异。慢性阻塞性肺疾病急性加重期患者血清C-反应蛋白、血沉和脂联素水平显著高于稳定期患者(P<0.001，P=0.033和P=0.024)，而瘦素和NO水平差异无统计学意义。稳定期COPD组血清脂联素水平与FEV1、FEV1/FVC、呼吸困难评分、BMI等炎症指标均无相关性。稳定期COPD组CRP、ESR与FEV1呈负相关。结论。脂联素可能是COPD低度全身炎症反应的标志物。血清脂联素在急性加重期的进一步升高表明，这也可能是急性加重期的生物标志物，与CRP和ESR一样。
Background and objective. Adiponectin is an adipose tissue-derived specific protein that has a role in energy homeostasis, that has a protective role against the development of insulin resistance and atherosclerosis and that exhibits anti-inflammatory properties. We investigated serum adiponectin as a biomarker of systemic inflammatory response and its relation with leptin, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and nitric oxide (NO) in chronic obstructive pulmonary disease (COPD) patients. Material and methods. We studied 36 male patients with COPD (15 stable and 21 exacerbated) and 17 age and sex-matched healthy subjects. The adiponectin and leptin levels were measured by enzyme-linked immunosorbent assay. Serum CRP levels were measured using the nephelometric method. ESR was determined using the Westergren method and NO by the cadmium reduction method. Results. Adiponectin levels in COPD patients were significantly higher than those in control subjects (p0.001), whereas there were no differences in leptin or NO levels. Serum levels of CRP, ESR and adiponectin were significantly higher in the exacerbated COPD patients compared to the stable group (p0.001, p=0.033 and p=0.024, respectively), whereas the differences in leptin and NO levels were not significant. Serum levels of adiponectin were not correlated with FEV1, FEV1/FVC, dyspnoea score, BMI or other inflammatory parameters in the stable COPD group. CRP and ESR correlated negatively with FEV1 in the stable COPD group. Conclusions. Adiponectin may be a marker of low-grade systemic inflammatory response in COPD. A further rise in serum adiponectin in the exacerbation period denotes that this may also be a biomarker of the exacerbation phase as well as CRP and ESR.