The medial frontal cortex and the rapid processing of monetary gains and losses
The medial frontal cortex and the rapid processing of monetary gains and losses
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DOI：
10.1126/science.1066893
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发表时间：
2002-03-22
期刊：
影响因子：
56.9
通讯作者：
Willoughby, AR
中科院分区：
文献类型：
--
作者：
Gehring, WJ;Willoughby, AR
我们报告了在结果刺激后265毫秒内发生的神经处理的观察，这些结果刺激告知人类参与者在赌博任务中的收益和损失。负极性事件相关脑电位可能是由前扣带皮层内或附近的内侧额叶区域产生的，当参与者在两个选项中做出选择时，其幅度要大于当它导致收益时的幅度。对损失的敏感性并不仅仅是检测到错误的反映;当替代选择会产生更大的收益时，收益不会引发内侧额叶活动，而即使当替代选择会产生更大的损失时，损失也会引发这种活动。在损失后做出的选择比在收益后做出的选择风险更大，并且与更大的折腾相关活动有关。由此可见，内侧额叶计算可能有助于参与更高层次决策的心理状态，包括经济选择。
We report the observation of neural processing that occurs within 265 milliseconds after outcome stimuli that inform human participants about gains and losses in a gambling task. A negative-polarity event-related brain potential, probably generated by a medial-frontal region in or near the anterior cingulate cortex, was greater in amplitude when a participant's choice between two alternatives resulted in a toss than when it resulted in a gain. The sensitivity to losses was not simply a reflection of detecting an error; gains did not elicit the medial-frontal activity when the alternative choice would have yielded a greater gain, and losses elicited the activity even when the alternative choice would have yielded a greater loss. Choices made after losses were riskier and were associated with greater toss-related activity than choices made after gains. It follows that medial-frontal computations may contribute to mental states that participate in higher level decisions, including economic choices.