A Network Approach to Study Karyotypic Evolution: The Chromosomal Races of the Common Shrew (Sorex araneus) and House Mouse (Mus musculus) as Model Systems
A Network Approach to Study Karyotypic Evolution: The Chromosomal Races of the Common Shrew (Sorex araneus) and House Mouse (Mus musculus) as Model Systems
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DOI：
10.1093/sysbio/syq004
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发表时间：
2010-05-01
影响因子：
6.5
通讯作者：
Searle, Jeremy B.
中科院分区：
文献类型：
--
作者：
White, Thomas A.;Bordewich, Magnus;Searle, Jeremy B.
从核型数据重建系统发育的方法的发展落后于分子和形态学特征所取得的成就。这阻碍了我们对染色体重排在物种形成中的作用的理解，这取决于对最近物种形成的形式之间以及未来可能物种形成的物种内的形式之间的核型关系的了解。在这里，我们提出了一种重建染色体系统发育的新方法。我们的方法涉及使用网络，我们相信网络为染色体系统发育分析的分叉系统发育树提供了一种灵活的替代方案，并且可以纳入广泛的染色体突变，并允许通过杂交进行网状进化。在本文中，我们在种内水平上应用我们的方法，以最小进化步骤数来建立普通鼩鼱（Sorex araneus）和家鼠（Mus musculus）染色体种族的系统发育史。之前曾多次尝试重建鼩鼱和小鼠染色体种族的系统发育，但我们描述了第一个基于计算机的分析，该分析考虑了产生新种族的所有可能突变（罗伯逊融合和裂变以及全臂相互易位[WART]）以及为这些物种假设的其他种族生成过程（涉及近端着丝粒和重组峰的带状种族分化事件）。对普通鼩鼱染色体种族的分析揭示了带状种族和疣的重要性比迄今为止所建议的要大。
The development of methods to reconstruct phylogenies from karyotypic data has lagged behind what has been achieved with molecular and morphological characters. This hampers our understanding of the role of chromosomal rearrangements in speciation, which depends on knowledge of the karyotypic relationships both among forms that have recently speciated and among forms within species that may speciate in the future. Here, we present a new approach to reconstruct chromosomal phylogenies. Our approach involves the use of networks, which we believe offer a flexible alternative to bifurcating phylogenetic trees for chromosomal phylogenetic analyses, and can incorporate a wide range of chromosomal mutations as well as allowing reticulate evolution through hybridization. In this paper, we apply our method at the within-species level to establish the phylogenetic history, in terms of minimum number of evolutionary steps, of chromosomal races within both the common shrew (Sorex araneus) and the house mouse (Mus musculus). There have been several previous attempts to reconstruct the phylogenies of chromosomal races within shrews and mice, but we describe the first computer-based analysis that considers the whole range of possible mutations generating new races (Robertsonian fusions and fissions and whole-arm reciprocal translocations [WARTs]) and other race-generating processes (zonal raciation events involving both acrocentric and recombinant peaks) postulated for these species. The analysis for common shrew chromosomal races reveals a greater importance of zonal raciation and WARTs than has been suggested hitherto.