Infection-specific particle from the unconventional slow virus diseases.
Infection-specific particle from the unconventional slow virus diseases.
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来自非常规慢病毒疾病的感染特异性颗粒。
DOI：
10.1126/science.6377496
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Gajdusek,DC
中科院分区：
文献类型：
--
作者：
Merz,PA;Rohwer,RG;Kascsak,R;Wisniewski,HM;Somerville,RA;GibbsJr,CJ;Gajdusek,DC
痒病相关的纤维，首先在感染痒病的小鼠的大脑中观察到，也在感染痒病的仓鼠和猴子中观察到，在患有克雅氏病的人类中，以及在库鲁感染的猴子中。这些原纤维未发现在一个全面的系列控制大脑从人类和动物的中枢神经系统疾病的影响，导致组织病理学，超微结构特征，或疾病症状类似的瘙痒症，库鲁病，克雅氏病。这些原纤维也在临床前瘙痒症和瘙痒症感染小鼠的脾脏中发现;它们是“非常规”慢病毒疾病的特异性标志物，并且可能是病原体。
Scrapie-associated fibrils, first observed in brains of scrapie-infected mice, were also observed in scrapie-infected hamsters and monkeys, in humans with Creutzfeldt-Jakob disease, and in kuru-infected monkeys. These fibrils were not found in a comprehensive series of control brains from humans and animals affected with central nervous system disorders resulting in histopathologies, ultrastructural features, or disease symptoms similar to those of scrapie, kuru, and Creutzfeldt-Jakob disease. These fibrils are also found in preclinical scrapie and in the spleens of scrapie-infected mice; they are a specific marker for the "unconventional" slow virus diseases, and may be the etiological agent.