Self-assembled phenylalanine-α,β-dehydrophenylalanine nanotubes for sustained intravitreal delivery of a multi-targeted tyrosine kinase inhibitor.
Self-assembled phenylalanine-α,β-dehydrophenylalanine nanotubes for sustained intravitreal delivery of a multi-targeted tyrosine kinase inhibitor.
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自组装苯丙氨酸-α,β-脱氢苯丙氨酸纳米管用于持续玻璃体内递送多靶点酪氨酸激酶抑制剂。
DOI：
10.1016/j.jconrel.2013.09.016
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Kompella,UdayB
中科院分区：
文献类型：
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作者：
Panda,JibanJ;Yandrapu,Sarath;Kadam,RajendraS;Chauhan,ViranderS;Kompella,UdayB
委员会得出的结论是，作者Kadam通过操纵LC-MS/MS峰面积数据故意篡改和/或捏造结果，以平滑动力学和/或改变图6的统计学显著性。篡改药物帕唑帕尼的标准曲线，使其呈线性。事实上，标准曲线的原始数据是高度分散和非线性的，导致标准曲线无法使用。因此，从所制造的曲线计算的帕唑帕尼值是完全不可靠的。
The Committee has come to the conclusion that author Kadam has knowingly and intentionally falsified and/or fabricated results by manipulating LC-MS/MS peak area data to smooth kinetics and/or alter statistical significance for Figure 6.The standard curve for the drug pazopanib was falsified to make it appear linear. In fact, the raw data for the standard curves were highly scattered and non-linear, resulting in an unusable standard curve. As a result, the pazopanib values calculated from the fabricated curve are completely unreliable.