Rhodium-Catalyzed Enantioselective [2 + 2 + 1] Cycloaddition of 1,6-Enynes with Cyclopropylideneacetamides
Rhodium-Catalyzed Enantioselective [2 + 2 + 1] Cycloaddition of 1,6-Enynes with Cyclopropylideneacetamides
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铑催化的对映选择性 [2 2 1] 1,6-烯炔与环丙叉乙酰胺的环加成
DOI：
10.1021/acs.orglett.8b03235
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发表时间：
2018
期刊：
影响因子：
5.2
通讯作者：
Tanaka Ken
中科院分区：
文献类型：
--
作者：
Suzuki Shunsuke;Nishigaki Shuhei;Shibata Yu;Tanaka Ken
已经确定，阳离子铑(I)/(R)-tol-BINAP或(R)-BINAP络合物可在室温下催化具有单取代烯烃单元的1,6-烯炔与亚环丙基乙酰胺的对映选择性[2 + 2 + 1]环加成反应，通过消除乙烯生成双环(环戊-2-en-1-亚基)乙酰胺，对映选择性。
It has been established that a cationic rhodium(I)/(R)-tol-BINAP or (R)-BINAP complex catalyzes the enantioselective [2 + 2 + 1] cycloaddition of 1,6-enynes, possessing monosubstituted alkene units, with cyclopropylideneacetamides at room temperature through the elimination of ethylene to give bicyclic (cyclopent-2-en-1-ylidene)acetamides with high enantioselectivity.