Containment of an Outbreak of KPC-3-Producing Klebsiella pneumoniae in Italy
Containment of an Outbreak of KPC-3-Producing Klebsiella pneumoniae in Italy
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DOI：
10.1128/jcm.01242-11
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发表时间：
2011-11-01
影响因子：
9.4
通讯作者：
Tsakris, Athanassios
中科院分区：
文献类型：
--
作者：
Agodi, Antonella;Voulgari, Evangelia;Tsakris, Athanassios
从2009年3月至2009年5月，从意大利重症监护室（ICU）住院的16例患者中回收了24株碳青霉烯类耐药肺炎克雷伯菌分离株。所有分离株均含有KPC-3碳青霉烯酶，属于多位点序列类型258（命名为ST 258）的单一脉冲场凝胶电泳（PFGE）克隆。实施了多模式感染控制计划，并控制了产KPC-3的K.肺炎克隆最终得到控制，而无需关闭ICU。加强感染控制措施和严格监测员工的依从性是控制疫情的必要条件。
From March 2009 to May 2009, 24 carbapenem-resistant Klebsiella pneumoniae isolates were recovered from 16 patients hospitalized in an Italian intensive care unit (ICU). All isolates contained KPC-3 carbapenemase and belonged to a single pulsed-field gel electrophoresis (PFGE) clone of multilocus sequence type 258 (designated as ST258). A multimodal infection control program was put into effect, and the spread of the KPC-3-producing K. pneumoniae clone was ultimately controlled without closing the ICU to new admissions. Reinforced infection control measures and strict monitoring of the staff adherence were necessary for the control of the outbreak.