Insights into the biological functions of Dock family guanine nucleotide exchange factors.
Insights into the biological functions of Dock family guanine nucleotide exchange factors.
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DOI：
10.1101/gad.236349.113
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发表时间：
2014-03-15
影响因子：
10.5
通讯作者：
Côté JF
中科院分区：
文献类型：
--
作者：
Laurin M;Côté JF
Rho GTPases在发育过程中调节许多重要的过程，但它们通过鸟嘌呤核苷酸交换因子（GEF）的上游调节的全部影响才刚刚开始受到重视。在这篇综述中，Laurin和Litté专注于哺乳动物Dock家族的GEFs在发育和疾病中的新兴生物学功能，并讨论了最近的发现如何被用于新的治疗策略。Rho GTP酶在胚胎发育的许多方面发挥关键的调节作用，调节诸如分化、增殖、形态发生和迁移的过程。在后生动物中发现的两个鸟嘌呤核苷酸交换因子（GEF）家族，Dbl和Dock，负责Rac和Cdc42蛋白及其下游信号通路的时空激活。本文综述了哺乳动物DOCK家族在发育和疾病中的新作用。我们还讨论了，如果可能的话，如何最近发现的生物功能，这些GEFs可能会被利用开发新的治疗策略。
Rho GTPases regulate many essential processes during development, yet the full impact of their upstream regulation through guanine nucleotide exchange factors (GEFs) is only beginning to be appreciated. In this review, Laurin and Côté focus on emerging biological functions of the mammalian Dock family of GEFs in development and disease and discuss how recent discoveries might be exploited for novel therapeutic strategies. Rho GTPases play key regulatory roles in many aspects of embryonic development, regulating processes such as differentiation, proliferation, morphogenesis, and migration. Two families of guanine nucleotide exchange factors (GEFs) found in metazoans, Dbl and Dock, are responsible for the spatiotemporal activation of Rac and Cdc42 proteins and their downstream signaling pathways. This review focuses on the emerging roles of the mammalian DOCK family in development and disease. We also discuss, when possible, how recent discoveries concerning the biological functions of these GEFs might be exploited for the development of novel therapeutic strategies.
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