Impact of smoking abstinence on working memory neurocircuitry in adolescent daily tobacco smokers
Impact of smoking abstinence on working memory neurocircuitry in adolescent daily tobacco smokers
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DOI：
10.1007/s00213-007-0797-9
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发表时间：
2007-09-01
影响因子：
3.4
通讯作者：
Pugh, Kenneth R.
中科院分区：
文献类型：
--
作者：
Jacobsen, Leslie K.;Mencl, W. Einar;Pugh, Kenneth R.
原理支持工作记忆的神经回路的有效功能发生在多巴胺神经传递的狭窄范围内。在啮齿动物上的研究表明，青春期接触尼古丁会导致尼古丁戒断，皮质和皮质下多巴胺神经传递发生紧急变化。目的测试支持工作记忆的神经回路效率在青少年日常吸烟者急性戒烟过程中发生变化的证据。材料与方法使用功能磁共振成像对55名青少年日常吸烟者和38名不吸烟者进行比较，同时受试者进行言语工作记忆任务。对吸烟者在吸烟期间和戒烟24小时后进行研究。结果与不吸烟者相比，吸烟者在高工作记忆负荷的任务中表现出更高的言语工作记忆神经回路成分的激活，包括左额叶腹外侧部和左下顶叶。在戒烟过程中，吸烟者没有表现出工作记忆神经回路各组成部分之间的功能连接增加，而在不吸烟的青少年和既往的成人研究中观察到工作记忆负荷的增加。结论青少年吸烟者戒烟与工作记忆神经回路各组成部分之间的功能协调改变和工作记忆神经回路的效率降低有关。这些变化可能源于青少年发育过程中尼古丁暴露对儿茶酚胺能系统的影响。
Rationale Efficient function of neurocircuitry that supports working memory occurs within a narrow range of dopamine neurotransmission. Work in rodents has shown that exposure to nicotine during adolescence leads to nicotine withdrawal emergent alterations in cortical and subcortical dopamine neurotransmission.Objectives To test for evidence that the efficiency of neurocircuitry supporting working memory is altered during acute smoking abstinence in adolescent daily tobacco smokers.Materials and methods Fifty-five adolescent daily tobacco smokers were compared with 38 nonsmokers using functional magnetic resonance imaging while subjects performed a verbal working memory task. Smokers were studied during smoking and after 24 h of abstinence from tobacco use.Results Performance of a task with high working memory load in the context of smoking abstinence was associated with greater activation of components of the verbal working memory neurocircuit, including left ventrolateral prefrontal cortex and left inferior parietal lobe, among smokers relative to nonsmokers. During smoking abstinence, smokers failed to exhibit increases in functional connectivity between components of the working memory neurocircuit with increasing working memory load observed in nonsmoking adolescents and in prior studies of adults.Conclusions Smoking abstinence in adolescent smokers is associated with reductions in the efficiency of working memory neurocircuitry and alterations in the functional coordination between components of the working memory neurocircuit. These alterations may stem from effects of nicotine exposure on catecholaminergic systems during adolescent development.