COMPARISON OF GLUCOSE, SORBITOL AND FRUCTOSE ACCUMULATION IN LENS AND LIVER OF DIABETIC AND INSULIN-TREATED RATS AND MICE
COMPARISON OF GLUCOSE, SORBITOL AND FRUCTOSE ACCUMULATION IN LENS AND LIVER OF DIABETIC AND INSULIN-TREATED RATS AND MICE
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DOI：
10.1016/0305-0491(89)90250-2
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发表时间：
1989-01-01
影响因子：
2.2
通讯作者：
WATKINS, JB
中科院分区：
文献类型：
--
作者：
GAYNES, BI;WATKINS, JB
1. 测定了正常、链脲霉素诱导的糖尿病和胰岛素治疗的糖尿病大鼠和小鼠的晶状体、肝脏和血液中葡萄糖、果糖和山梨醇的积累。2. 山梨醇在大鼠晶状体中的浓度是小鼠晶状体的10-100倍，以糖尿病动物的浓度最高。3. 大鼠和小鼠肝脏以及小鼠晶状体中的山梨醇含量相似，在高血糖状态下仅略有增加。4. 果糖积累在大鼠和小鼠肝脏中相似，在糖尿病小鼠血液和糖尿病大鼠晶状体中升高。5. 大鼠晶状体醛糖还原酶活性约为小鼠晶状体的350倍。6. 大鼠晶状体山梨醇脱氢酶活性约为小鼠晶状体的10倍。7. 在糖尿病大鼠和小鼠中，胰岛素倾向于降低肝糖和随后山梨醇的形成。
1. The accumulation of glucose, fructose, and sorbitol was determined in the lens, liver, and blood from normal, streptozotocin-induced diabetic, and insulin-treated diabetic rats and mice. 2. Sorbital concentration in rat lens was 10-100 times greater than that in mouse lens, with the highest concentrations in the diabetic animals. 3. Sorbital levels in rat and moue liver, and mouse lens were similar and increased only slightly under hyperlgycemic conditions. 4. Fructose accumulation was similar in rat and mouse liver and was elevated in the diabetic mouse blood and diabetic rat lens. 5. Aldose reductase activity in rat lens was approximately 350 times that of mouse lens. 6. Lenticular sorbitol dehydrogenase activity in rats was approximately ten times that in mouse lens. 7. Administration of insulin tended to lower liver glucose and subsequent sorbitol formation in the diabetic rat and mouse.