Magnetic Self-Healing Hydrogel from Difunctional Polymers Prepared via the Kabachnik-Fields Reaction
Magnetic Self-Healing Hydrogel from Difunctional Polymers Prepared via the Kabachnik-Fields Reaction
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DOI：
10.1021/acsmacrolett.1c00720
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发表时间：
2021-12-16
影响因子：
7.015
通讯作者：
Tao, Lei
中科院分区：
文献类型：
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作者：
He, Xianzhe;Zeng, Yuan;Tao, Lei
由于无法方便地引入能够有效稳定这些磁性纳米颗粒的基团，因此开发含有良好分散的磁性纳米颗粒的高质量磁性自修复水凝胶一直是一个具有挑战性的过程。在本研究中，通过Kabachnik-Fields（KF）反应开发了一种同时含有苯基硼酸（PBA）和膦酸（PA）基团的聚合物。该聚合物通过PA基团与氧化铁纳米颗粒（IONP）表面之间的强相互作用而良好地分散IONP;因此，该聚合物有效地混合IONP和聚（乙烯醇）（PVA）以形成含有良好分散的IONP的水凝胶。由于动态硼酸酯键，所得水凝胶是自修复的。此外，IONP的存在赋予了水凝胶磁性，也使其在交变磁场中具有热响应性，并扩大了其作为磁共振成像造影剂的应用。磁性自愈合水凝胶在动物实验中显示出优异的生物安全性，表明其作为生物和医学应用的可注射植入材料的潜力。这项研究利用了一种具有良好分散的IONP的生物相容性磁性自修复水凝胶，证明了KF反应在功能聚合物和智能材料开发中的价值，这可能会促进跨学科领域多组分反应的广泛研究。
The development of high quality magnetic self-healing hydrogels containing well-dispersed magnetic nanoparticle has been a challenging procedure due to unavailable methods of facilely introducing groups that can efficiently stabilize these magnetic nanoparticles in the self-healing hydrogels. In this research, a polymer containing both phenylboronic acid (PBA) and phosphonic acid (PA) groups has been developed by the Kabachnik-Fields (KF) reaction. This polymer well disperses iron oxide nanoparticles (IONPs) through the strong interactions between the PA groups and the surface of the IONPs; thus, this polymer effectively mixed IONPs and poly(vinyl alcohol) (PVA) to form a hydrogel containing well-dispersed IONPs. The resulting hydrogel is self-healing, owing to the dynamic borate ester linkages. Moreover, the presence of the IONPs endowed the hydrogel with magnetic properties, also making it heat-responsive in an alternating magnetic field and expanding its application as a contrast agent for magnetic resonance imaging. The magnetic self-healing hydrogel showed excellent biosafety properties in animal experiments, suggesting its potential as an injectable implant material for biological and medical applications. This research exploits a biocompatible magnetic self-healing hydrogel with well-dispersed IONPs, demonstrating the value of the KF reaction in the development of functional polymers and smart materials, which might prompt a broad study of multicomponent reactions in interdisciplinary fields.