EFFECTS OF STRESSFUL LIFE EVENTS ON BOWEL SYMPTOMS - SUBJECTS WITH IRRITABLE-BOWEL-SYNDROME COMPARED WITH SUBJECTS WITHOUT BOWEL DYSFUNCTION

EFFECTS OF STRESSFUL LIFE EVENTS ON BOWEL SYMPTOMS - SUBJECTS WITH IRRITABLE-BOWEL-SYNDROME COMPARED WITH SUBJECTS WITHOUT BOWEL DYSFUNCTION
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DOI：
10.1136/gut.33.6.825
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发表时间：
1992-06-01
期刊：
GUT
影响因子：
24.5
通讯作者：
SCHUSTER, MM
SCHUSTER, MM
中科院分区：
医学1区
文献类型：
--
作者：
WHITEHEAD, WE;CROWELL, MD;SCHUSTER, MM

文献摘要

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一份标准化的应激生活事件清单和肠道症状问卷在一年中每隔三个月对383名未被选为肠道症状的女性进行了测试。一份新人格问卷最初是用来评估神经质的。将符合肠易激综合征限制性诊断标准的受试者与主诉腹痛和排便习惯改变但不符合限制性诊断标准(功能性肠病)的受试者和没有肠道功能障碍的对照组进行比较。即使在统计上控制了神经质的混杂影响时，肠易激症状组的压力水平也明显高于其他两组。时间滞后相关分析显示，在三个月的间隔中，所有组的应激与随后三个月间隔中的肠道症状显著相关。在3个月和6个月时，肠易激综合征组的压力与肠道症状相关的回归线的斜率明显大于其他两组，这表明肠易激综合征的受试者对压力的反应性更强。压力得分也与残疾天数和因肠道症状就诊的次数显著相关。
A standardised inventory of stressful life events and a bowel symptom questionnaire were administered at three month intervals for one year to 383 women who were unselected with respect to bowel symptoms. A NEO Personality Inventory was given initially to assess neuroticism. Subjects who satisfied restrictive diagnostic criteria for irritable bowel syndrome were compared with those who complained of abdominal pain plus altered bowel habits but who did not meet restrictive diagnostic criteria (functional bowel disorder) and with controls without bowel dysfunction. The irritable bowel group showed significantly higher levels of stress than the other two groups even when the confounding effects of neuroticism were statistically controlled for. Time lagged correlations showed that stress in one three month interval was significantly correlated with bowel symptoms in the subsequent three month interval for all groups. The slope of the regression line relating stress to bowel symptoms was significantly steeper for the irritable bowel group than for the other two groups at three and six months, suggesting that subjects with irritable bowel syndrome show a greater reactivity to stress. Stress scores were also significantly correlated with the number of disability days and the number of medical clinic visits for bowel symptoms.