Methanol extract of Sorbus commixta cortex prevents vascular inflammation in rats with a high fructose-induced metabolic syndrome
Methanol extract of Sorbus commixta cortex prevents vascular inflammation in rats with a high fructose-induced metabolic syndrome
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DOI：
10.1142/s0192415x07004801
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发表时间：
2007-01-01
影响因子：
5.7
通讯作者：
Lee, Ho Sub
中科院分区：
文献类型：
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作者：
Kang, Dae Gill;Sohn, Eun Jin;Lee, Ho Sub
给大鼠喂食高果糖(FRC)会导致血压适度升高，这与胰岛素抵抗有关。本研究旨在评价花椒皮甲醇提取物(MSC)对高脂饲料诱导的代谢综合征大鼠血管炎症的影响。将雄性SD大鼠分为4组，每组6只，分别为：1)对照组，2)高FRC组，3)FRC/MSC1组，高FRC组给予MSC(100 mg/kg/d)，4)FRC/MSC2组，高FRC组给予MSC(200 mg/kg/d)。高剂量FRC可降低主动脉内皮型一氧化氮合酶(EcNOS)的表达水平，而MSC可恢复cGMP(CGMP)的生成。相反，MSC可抑制血管炎症相关细胞因子、转录因子ET-1和黏附分子表达水平的升高。此外，在高FRC饮食组，MSC治疗显示减轻了主动脉内膜和中层的增厚。我们的研究结果表明，MSC可能对高FRC诱导的代谢综合征大鼠具有抗血管炎症作用。
Feeding high fructose (Frc) to rats induces a moderate increase in blood pressure, which is associated with insulin resistance. The present study was designed to evaluate the effect of the methanol extract of Sorbus commixta cortex (MSC) on vascular inflammation in a rat model of the metabolic syndrome induced by a high Frc-diet. Male Sprague-Dawley rats were divided into 4 groups and treated for 7 weeks as follows: 1) control, 2) high Frc-diet group, 3) Frc/MSC1 group; high Frc-diet group treated with MSC (100 mg/kg/day), and 4) Frc/MSC2 group; high Frc-diet group treated with MSC (200 mg/kg/day). High Frc-induced decreases of the expression level of aortic endothelial nitric oxide synthase (ecNOS) while the production of cyclic GMP (cGMP) was restored by treatment with MSC. On the contrary, increases of the expression level of endothelin-1 (ET-1) in the aorta, the transcription factor, the cytokine related with vascular inflammation, and the adhesion molecules were suppressed by MSC treatment. Moreover, MSC treatment was shown to lessen the thickening noted in the aortic intima and media of the high Frc-diet group. Our findings suggest that MSC may have an anti-vascular inflammatory effect on rats with a high Frc-induced metabolic syndrome.