Molecular Aspects of Head and Neck Cancer Therapy.
Molecular Aspects of Head and Neck Cancer Therapy.
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DOI：
10.1016/j.hoc.2015.07.003
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Rocco JW
中科院分区：
文献类型：
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作者：
Puram SV;Rocco JW
尽管对头颈部肿瘤生物学的理解迅速扩大，以及放射、化学疗法和手术治疗方式的优化，但头颈部鳞状细胞癌（HNSCC）仍然是癌症相关发病率和死亡率的主要原因。虽然我们对这些肿瘤的生物学理解在很大程度上限于驱动增殖，存活和分化的途径，但HPV作为HNSCC，特别是口咽SCC的主要驱动因素的鉴定，以及最近对HNSCC的基因组测序分析，极大地影响了我们对致癌背后的潜在生物学的理解，部分影响了我们的治疗方法。特别是，我们正处于一个主要的分子和临床十字路口，有前途的诊断和治疗药物的爆炸，具有很大的希望。在这里，我们总结了我们目前对HNSCC生物学的理解，包括对最近测序分析的回顾，并确定了潜在诊断和治疗药物的有前途的领域。
In spite of a rapidly expanding understanding of head and neck tumor biology as well as optimization of radiation, chemotherapy, and surgical treatment modalities, head and neck squamous cell carcinoma (HNSCC) remains a major cause of cancer related morbidity and mortality. Although our biologic understanding of these tumors had largely been limited to pathways driving proliferation, survival, and differentiation, the identification of HPV as a major driver of HNSCC, specifically oropharyngeal SCC, as well as recent genomic sequencing analyses of HNSCC has dramatically influenced our understanding of the underlying biology behind carcinogenesis, and in part, our approach to therapy. In particular, we are at a major molecular and clinical crossroads with an explosion of promising diagnostic and therapeutic agents that hold great promise. Here, we summarize our current understanding of HNSCC biology, including a review of recent sequencing analyses, and identify promising areas for potential diagnostic and therapeutic agents.